NCT07834333Recruiting
Effectiveness of Theta Burst Stimulation For Upper and Lower Extremity Recovery in Stroke
Effects of Different Theta Burst Stimulation Protocols Combined With Conventional Rehabilitation on Upper and Lower Extremity Motor Recovery in Patients With Early-Stage Stroke
Source: ClinicalTrials.gov · Last updated 22 Sept 2026
Brief summary (registry, in English)
This single-center, single-blind, randomized, sham-controlled clinical trial will include 60 patients aged \>45 years who are within 3 months of a first-ever middle cerebral artery ischemic stroke. Participants will be randomized into four groups: coupled TBS (contralesional cTBS followed by ipsilesional iTBS), cTBS plus sham iTBS, sham cTBS plus iTBS, or sham TBS. TBS will be delivered over the primary motor cortex for 10 sessions over 2 weeks. Stimulation intensity will be set at 80% of the resting motor threshold determined using EMG-guided motor evoked potentials. Each cTBS and iTBS application will consist of 600 pulses. All participants will additionally receive standardized conventional rehabilitation for at least 4 weeks. The primary outcome will be upper-extremity motor recovery assessed using the motor domain of the Fugl-Meyer Assessment. Secondary outcomes will include lower-extremity motor recovery, spasticity, sensory function, cortical excitability, functional ambulation, activities of daily living, and stroke-specific quality of life. Assessments will be performed at baseline, after the 2-week intervention, and at 1-month post-treatment follow-up.
- Status (registry)
- Recruiting
- Study type
- Interventional
- Enrollment
- 60 (estimated)
- First submitted
- 28 Aug 2026
- Start date
- 30 Sept 2026
- Primary completion date
- 30 Aug 2027
- Lead sponsor
- Ankara Etlik City Hospital
- Diseases
- Stroke
- NCT number
- NCT07834333
What you commit to
- Study type: Interventional
- Planned participants: 60
- From 30 Sept 2026 to the primary completion date, 30 Aug 2027
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Metallic implants in the brain or scalp, including cochlear implants.
- Alcohol and/or drug dependence.
Other illness
- History of epilepsy.
- Neurological disease other than stroke.
- History of brain surgery.
- Comorbid disease that may significantly impair general health, such as heart f-failure or chronic obstructive pulmonary disease, and/or severe infection.
- Diagnosis of malignancy.
- Peripheral nerve injury and/or musculoskeletal disorder affecting motor function of the upper or lower extremities, such as fracture.
- Cardiac arrhythmia.
- Visual or hearing impairment that prevents communication.
- Refusal to participate or failure to provide informed consent.
Other
- Presence of a pacemaker.
- Pregnancy.
- Aphasia, spatial neglect, or visual field loss.
Who the study is looking for
- Diagnosis of ischemic stroke due to middle cerebral artery (MCA) occlusion confirmed by magnetic resonance imaging (MRI).
- Within the first 3 months after stroke.
- First-ever stroke.
- Age ≥45 years.
- Brunnstrom stage 1, 2, or 3 for the upper extremity and hand.
- No previous physical therapy after the current stroke.
- Ability to maintain at least minimal semi-sitting balance.
- Medically and neurologically stable.
- Mini-Mental State Examination score \>24.
- Native Turkish speaker who voluntarily agrees to participate and provides written informed consent.
Age in the registry: 45 years to - · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Ankara Etlik Sehir Hastanesi Coordinator of this site? Confirm its status | Ankara | Turkey (Türkiye) | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.