NCT07835828Recruiting
Optimised Cardiovascular and Renal Protection in Patients With Chronic Kidney Disease and Cardiovascular Disease
Optimised Multidisciplinary Cardiovascular and Renal Protection in Patients With Chronic Kidney Disease and Cardiovascular Disease: Effects on Diastolic Function, Cardiovascular and Renal Outcomes
Source: ClinicalTrials.gov · Last updated 15 Oct 2026
Brief summary (registry, in English)
The goal of this clinical trial is to investigate whether care in a specialised Cardio-Renal Clinic can improve the health of people living with both cardiovascular disease and chronic kidney disease. The clinic brings together expertise in heart and kidney disease and provides structured treatment based on current clinical guidelines. The main research questions are: * After one year, does care in the Cardio-Renal Clinic improve measures of heart and kidney function, quality of life, symptoms, and physical ability compared with usual care? * After five years, does care in the Cardio-Renal Clinic reduce the risk of death, hospitalisation for heart failure, heart attack, stroke, worsening kidney function, or kidney failure compared with usual care? At the beginning of the study, all participants will undergo a detailed assessment of heart and kidney health. This will include blood and urine tests, an ultrasound examination of the heart, questionnaires, and tests of physical ability. Participants will then be randomly assigned to either optimised care in the Cardio-Renal Clinic or usual care. Participants assigned to the Cardio-Renal Clinic will have treatment reviewed and adjusted by a multidisciplinary team. The clinic may recommend or prescribe approved medications that are already used in routine care for heart and kidney disease. No experimental medications will be used. Participants assigned to usual care will continue to receive care from a general practitioner and any hospital departments involved in treatment.
- Status (registry)
- Recruiting
- Study type
- Interventional
- Enrollment
- 500 (estimated)
- First submitted
- 17 Sept 2026
- Start date
- 1 Oct 2026
- Primary completion date
- 1 Oct 2038
- Lead sponsor
- Odense University Hospital
- Diseases
- Chronic kidney disease, Heart failure
- NCT number
- NCT07835828
What you commit to
- Study type: Interventional
- Planned participants: 500
- From 1 Oct 2026 to the primary completion date, 1 Oct 2038
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Patients receiving chronic dialysis or having of kidney transplant.
- Participation in another clinical trial with an investigational product or device that could interfere with the primary and/or secondary endpoints of this study.
Other illness
- Diabetes type I or II
- Inability to understand the study procedures, comply with study requirements, or presence of any condition that, in the opinion of the research staff, may interfere with the patient's ability to participate in or complete the study.
Lab values
- Established heart failure with reduced ejection fraction.
Age
- Expected life expectancy \<5 years.
Who the study is looking for
- Age ≥ 18 years old
- Capable of giving written informed consent
- Established chronic kidney disease, and at least two measurements of: 1) eGFR \<45 and \>15 mL/min/1.73 m², and/or 2) UACR \>200 mg/g, or 3) eGFR \<60 mL/min/1.73 m² and UACR \>30 mg/g.
- Established cardiovascular disease, including prior acute coronary syndrome, chronic coronary syndrome, objective evidence of myocardial ischaemia, non-coronary atherosclerotic cardiovascular diase (stroke or peripheral arterial disease), heart failure with preserved ejection fraction, atrial fibrillation and/or flutter, clinically significant valvular disease, or hypertension treated with three or more antihypertensive drugs.
Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Cardiovascular Research Unit, Odense University Hospital - Svendborg Coordinator of this site? Confirm its status | Svendborg | Denmark | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.