NCT07836881Completed
Effects of Supervised Exercise Training on Erythrocyte Deformability in Hemodialysis Patients
Effects of Supervised Exercise Training on Red Blood Cell Membrane Protein-Regulated Deformability in Patients With End-Stage Renal Disease Receiving Hemodialysis
Source: ClinicalTrials.gov · Last updated 23 Sept 2026
Brief summary (registry, in English)
This study evaluated red blood cell function and aerobic capacity in adults receiving maintenance hemodialysis and in healthy reference participants. Participants receiving hemodialysis were included in either a supervised exercise training group or a usual-care group. The supervised exercise program combined resistance and aerobic exercise performed before hemodialysis. Participants in the exercise group completed repeated assessments across a non-exercise observation period, exercise training, and post-training follow-up. The usual-care group continued usual care without supervised exercise training, and healthy participants served as a reference group. Assessments included cardiopulmonary exercise testing and blood sampling to evaluate aerobic capacity, red blood cell deformability, and red blood cell characteristics related to membrane function, cell shape, oxidative stress, and calcium-related responses.
- Status (registry)
- Completed
- Study type
- Interventional
- Enrollment
- 63 (actual)
- First submitted
- 12 Sept 2026
- Start date
- 24 Aug 2022
- Primary completion date
- 28 Dec 2025
- Lead sponsor
- Asia University
- Diseases
- Chronic kidney disease
- NCT number
- NCT07836881
What you commit to
- Study type: Interventional
- Participants enrolled: 63
- From 24 Aug 2022 to the primary completion date, 28 Dec 2025
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study design.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Hyperkalemia within the previous 3 months.
Other illness
- Orthopedic disease, muscle weakness, or other medical, physiological, or psychological conditions preventing exercise training or exercise testing.
- Implanted cardiac devices that prevented achievement of the heart rate required for exercise training.
Other
- Pregnancy or planned pregnancy within 1 year.
- Cardiovascular, metabolic, or other clinical contraindications to exercise testing or training.
Who the study is looking for
- Age 20 years or older
- For participants with end-stage renal disease: maintenance hemodialysis for more than 6 months, clinically stable during the previous 3 months, stable medical treatment for at least 6 weeks, nephrologist approval for participation, and Kt/V >1.2.
- For healthy reference participants: no history of kidney disease.
- Willingness to provide written informed consent.
Age in the registry: 20 years to - · Sex: All · Accepts healthy volunteers
Sites (1)
Sites in registry order. Save your city in your profile to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Chang Gung Memorial Hospital Coordinator of this site? Confirm its status | Taoyuan | Taiwan | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.