NCT07837050Not yet recruiting
Use of a Portable Pupillometer to Detect Optic Nerve Impairment in Patients With Suspected Multiple Sclerosis
Source: ClinicalTrials.gov · Last updated 23 Sept 2026
Brief summary (registry, in English)
In the diagnosis work-up of inflammatory disorders of the central nervous system (CNS), the assessment of optic nerve impairments, even in the absence of clinical symptoms, is now systematic, as it may shorten the time to diagnosis and facilitate early treatment initiation. Currently, optic nerve impairments can be assessed using three paraclinical examinations, namely magnetic resonance imaging (MRI), visual evoked potentials (VEP) or optic coherence tomography (OCT). However, these investigations are complex and resource-intensive. The development of a simple, reliable and easily accessible clinical tool could therefore facilitate the detection of optic nerve impairments. Unilateral or asymmetric optic nerve impairments, which are commonly observed in patients with inflammatory disorders of the CNS, translate into a reduction in efficiency of the pupillary light reflex, that can be detected by pupillometry. This technique consists in measuring pupil diameter and its variations and could represent a simple and convenient alternative to conventional investigations. The aim of this study is therefore to compare the results obtained using a portable pupillometer in patients suspected of having an inflammatory disorder of the CNS, with and without optic nerve impairment as detected by conventional methods (MRI, VEP and OCT).
- Status (registry)
- Not yet recruiting
- Study type
- Interventional
- Enrollment
- 100 (estimated)
- First submitted
- 10 Sept 2026
- Start date
- 24 Sept 2026
- Primary completion date
- 24 Sept 2027
- Lead sponsor
- Centre Hospitalier Universitaire de Nice
- Diseases
- Multiple sclerosis
- NCT number
- NCT07837050
What you commit to
- Study type: Interventional
- Planned participants: 100
- From 24 Sept 2026 to the primary completion date, 24 Sept 2027
- No sites listed in no country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Other
- Neurological or ophtamological history that could interfere with the interpretation of neuro-ophtalmological tests.
Who the study is looking for
- Patients aged 18 - 60 years old
- Patients sent to the CRC-SEP structure of the Nice hospital (CHU) with suspicion of a demyelinating disease
- Patients who underwent brain MRI with dedicated orbital sequences
- Patients who underwent a diagnostic work-up including VEP and OCT
- Patients affiliated to a social security system
- Patients who did not oppose to his participation in the clinical trial
Age in the registry: 18 years to 60 years · Sex: All · Does not accept healthy volunteers
This page is information, not medical advice. Discuss any trial with your doctor.