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NCT07837544Not yet recruiting

Diastolic Dysfunction and Inflammatory Biomarkers in Lupus Nephritis

Correlation Between Echocardiographic Parameters of Left Ventricular Diastolic Dysfunction and Inflammatory Biomarkers in Critically Ill Patients With Lupus Nephritis

Source: ClinicalTrials.gov · Last updated 24 Sept 2026

Brief summary (registry, in English)

This cross-sectional observational study aims to investigate the correlation between echocardiographic parameters of left ventricular diastolic dysfunction (E/A ratio, e', E/e' ratio, LAVI, and LVEF) and systemic inflammatory biomarkers (CRP, ESR, NLR, PLR, and SII) in critically ill patients with lupus nephritis. A total of 90 participants will be enrolled and divided into three groups: control group without SLE or lupus nephritis (n=30), SLE without lupus nephritis (n=30), and SLE with lupus nephritis (n=30). Transthoracic echocardiography and blood sampling for inflammatory biomarkers will be performed at baseline (ICU admission). The findings may help evaluate the potential role of these biomarkers in early cardiac risk assessment in this patient population.

Status (registry)
Not yet recruiting
Study type
Observational
Enrollment
90 (estimated)
First submitted
18 Sept 2026
Start date
20 Sept 2026
Primary completion date
20 Sept 2027
Lead sponsor
Assiut University
NCT number
NCT07837544

What you commit to

  • Study type: Observational
  • Planned participants: 90
  • From 20 Sept 2026 to the primary completion date, 20 Sept 2027
  • No sites listed in no country
  • Visits and tests: ask the trial team, the registry does not list them

Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.

Who cannot take part

Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.

Prior treatment

  • Pediatric patients \< 18 years
    • Patients with pre-existing primary cardiac disease unrelated to SLE (e.g., congenital heart disease, valvular heart disease, ischemic heart disease, cardiomyopathy)
    • Patients with poor echocardiographic acoustic window precluding adequate assessment of diastolic function
    • Patients with atrial fibrillation or other significant arrhythmias affecting Doppler-derived diastolic parameters
    • Patients with chronic kidney disease stage 5 on maintenance dialysis prior to the current critical illness
    • Patients with active sepsis-induced cardiomyopathy or septic shock where hemodynamic instability may confound diastolic function assessmentdiastolic function assessment.

Who the study is looking for

  • Adult patients ≥ 18 years
  • Patients diagnosed with Systemic Lupus Erythematosus fulfilling the 2019 EULAR/ACR criteria
  • Biopsy-proven or clinically diagnosed lupus nephritis admitted to the intensive care unit (ICU), regardless of the primary cause of admission
  • Patients who provided informed consent to undergo echocardiographic assessment and blood sampling for inflammatory biomarkers

Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers

Full criteria on ClinicalTrials.gov

This page is information, not medical advice. Discuss any trial with your doctor.