NCT07838636Recruiting
Effect of Physical Activity on the Course of Parkinson's Disease in Patients With Bilateral DBS-STN Stimulation.
Effect of Physical Activity on the Course of Parkinson's Disease in Patients With Bilateral DBS-STN Stimulation - a Randomized Controlled Trial.
Source: ClinicalTrials.gov · Last updated 6 Oct 2026
Brief summary (registry, in English)
Parkinson's disease is a common, progressive neurodegenerative disorder. The degeneration of dopaminergic neurons is associated with characteristic clinical symptoms such as tremor, rigidity, slowness of movement (bradykinesia) and postural instability. Subthalamic nucleus deep brain stimulation (DBS-STN) is a recognized and widely used method of treating advanced stages of Parkinson's disease. It improves clinical symptoms such as tremor, rigidity and slowness of movement (bradykinesia). This method has limited application for late motor and non-motor symptoms such as: akinesia, postural instability, gait, including the phenomenon of "freezing", recurrent falls, balance and dysarthria. These symptoms reduce the quality of life of patients and make them dependent on their caregivers. There is a clear need to develop additional forms of therapy that complement deep brain stimulation in controlling late motor and non-motor symptoms. Physical activity is a commonly used and recommended form of therapy for patients with Parkinson's disease and a complement to pharmacological therapy, improving gait, balance and quality of life. However, there are no clear recommendations including patients after implantation of DBS-STN stimulators to the group undergoing physiotherapy. To this day, only one clinical trial has been registered assessing the effect of physiotherapy on balance and gait in patients with DBS-STN.
- Status (registry)
- Recruiting
- Study type
- Interventional
- Enrollment
- 102 (estimated)
- First submitted
- 17 Sept 2026
- Start date
- 5 Sept 2024
- Primary completion date
- 5 Sept 2027
- Lead sponsor
- Medical University of Warsaw
- Diseases
- Parkinson disease
- NCT number
- NCT07838636
What you commit to
- Study type: Interventional
- Planned participants: 102
- From 5 Sept 2024 to the primary completion date, 5 Sept 2027
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Patients not eligible for advanced therapies with DBS-STN.
- Active malignancy or malignancy diagnosed and treated within 3 years prior to the study.
Other illness
- Patients diagnosed with dementia syndrome (MMSE \< 24/30).
- Diseases of the osteoarticular system and muscles that make it impossible to undergo rehabilitation.
- Severe kidney, liver and heart failure.
Age
- Age \<50 and \>70
Other
- Patients diagnosed with atypical parkinsonism.
- Hoehn \& Yahr Grade I and V.
Who the study is looking for
- Patients diagnosed with idiopathic Parkinson's disease (ICD-10:G20).
- Patients qualified for advanced therapies using DBS-STN.
- Grade II-IV on the Hoehn \& Yahr scale.
- Age 50-70.
- Consent to participate in the study.
Age in the registry: 50 years to 70 years · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Department of Neurology, Faculty of Health Sciences, Bródnowski Mazovian Hospital Coordinator of this site? Confirm its status | Warsaw | Poland | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.