NCT07840326RecruitingPhase 2
A Phase 2a Study of SUN-627 in Participants With Non-Active Secondary Progressive and Primary Progressive Multiple Sclerosis (SPMS/PPMS)
A Phase 2a, Randomized, Double-Blind, Placebo-Controlled Study of SUN-627 to Evaluate Safety, Tolerability, Pharmacokinetics, Pharmacodynamics, and Impact on Measures of Neuroinflammation in the Central Nervous System in Participants With Non-Active Progressive Multiple Sclerosis (SPMS/PPMS)
Source: ClinicalTrials.gov · Last updated 30 Oct 2026
Brief summary (registry, in English)
The goal of this Phase 2 clinical trial is to investigate the safety and tolerability of SUN-627 in men and women aged 18-70 years old with a diagnosis of non-active SPMS/PPMS.
- Status (registry)
- Recruiting
- Phase (registry)
- Phase 2
- Study type
- Interventional
- Enrollment
- 20 (estimated)
- First submitted
- 18 Sept 2026
- Start date
- 1 Oct 2026
- Primary completion date
- 30 Jun 2027
- Lead sponsor
- Sundance Biosciences, Inc.
- Diseases
- Multiple sclerosis
- NCT number
- NCT07840326
What you commit to
- Study type: Interventional · Phase 2
- Planned participants: 20
- From 1 Oct 2026 to the primary completion date, 30 Jun 2027
- 7 sites in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Use of certain medications or treatments before the study, or need for these treatments during the study
Other illness
- Certain abnormal heart rhythm findings on ECG or other heart conditions that may increase risk
- Certain serious or unstable medical conditions that could make the study unsafe
- Active infection, recent infection, or a history of repeated infections
- Additional inclusion and exclusion criteria are outlined in the full study protocol.
Other
- Current participation in another research study
Who the study is looking for
- Aged 18-70, inclusive
- Diagnosis of PPMS or non-active SPMS
- No MS relapses in the past 2 years
- Evidence that MS has continued to get worse over time
- A level of disability that fits the study requirements
Age in the registry: 18 years to 70 years · Sex: All · Does not accept healthy volunteers
Sites (7)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Local Institution - Site 102 Coordinator of this site? Confirm its status | Atlanta | United States | Recruiting |
| Local Institution - Site 104 Coordinator of this site? Confirm its status | Columbus | United States | Recruiting |
| Local Institution - Site 107 Coordinator of this site? Confirm its status | Dallas | United States | Not yet recruiting |
| Local Institution - Site 105 Coordinator of this site? Confirm its status | Oklahoma City | United States | Recruiting |
| Local Institution - Site 101 Coordinator of this site? Confirm its status | Raleigh | United States | Recruiting |
| Local Institution - Site 106 Coordinator of this site? Confirm its status | Stony Brook | United States | Not yet recruiting |
| Local Institution - Site 103 Coordinator of this site? Confirm its status | Tampa | United States | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.