NCT07841353Completed
Impact of Trikafta on P2X7R and Clinical Outcomes in Cystic Fibrosis
The Impact of Elexacaftor/Tezacaftor/Ivacaftor on P2X7R as Inflammatory Marker and Clinical Outcomes in Patients With Cystic Fibrosis
Source: ClinicalTrials.gov · Last updated 1 Oct 2026
Brief summary (registry, in English)
The aim of this study is to assess the response of the ETI on P2X7R level as inflammatory marker and clinical outcomes in patients with cystic fibrosis.
- Status (registry)
- Completed
- Study type
- Observational
- Enrollment
- 35 (actual)
- First submitted
- 8 Sept 2026
- Start date
- 25 Jul 2025
- Primary completion date
- 25 Jul 2026
- Lead sponsor
- Ain Shams University
- Diseases
- Cystic fibrosis
- NCT number
- NCT07841353
What you commit to
- Study type: Observational
- Participants enrolled: 35
- From 25 Jul 2025 to the primary completion date, 25 Jul 2026
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Other illness
- Known allergy or hypersensitivity to ETI or any of its components.
- Moderate hepatic impairment (Child-Pugh Class B) or severe hepatic impairment (Child-Pugh Class C).
- Presence of chronic inflammatory diseases unrelated to CF (e.g., Crohn's disease, glomerulonephritis, or thrombotic disorders) that could confound P2X7R levels.
Who the study is looking for
- Confirmed diagnosis of Cystic Fibrosis according to CF Foundation guidelines (based on positive sweat chloride test and/or presence of disease-causing mutations in homozygous state or compound heterozygous state in CFTR gene).
- Patients eligible for ETI therapy (having at least one F508del mutation or a mutation known to be responsive to ETI).
- Age above 5 years old.
Age in the registry: 5 years to - · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Ain Shams University Hospitals Coordinator of this site? Confirm its status | Cairo | Egypt | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.