NCT07841847Not yet recruiting
Effects of Personalized Cardiac Rehabilitation on miRNAs and Biochemical Biomarkers in Patients With Coronary Artery Disease
Changes in Specific miRNAs and Biochemical Biomarkers Following Personalized Cardiac Rehabilitation in Patients With Coronary Artery Disease
Source: ClinicalTrials.gov · Last updated 25 Sept 2026
Brief summary (registry, in English)
This prospective interventional study aims to investigate changes in specific microRNAs (miRNAs) and biochemical biomarkers following a personalized cardiac rehabilitation program in patients with coronary artery disease. A total of 46 participants aged 35-75 years who have undergone percutaneous coronary intervention or coronary artery bypass graft surgery and are eligible for cardiac rehabilitation will be included. Participants will complete a structured, individualized cardiac rehabilitation program lasting 6-8 weeks. Clinical assessments, cardiopulmonary exercise testing, and blood-based biomarker measurements will be performed before and after the rehabilitation program. The primary objective is to determine changes in miRNA and biochemical biomarker levels after cardiac rehabilitation and to evaluate the relationship between these changes and clinical improvement. The findings may contribute to a better understanding of biological responses to cardiac rehabilitation and support the development of more personalized rehabilitation strategies.
- Status (registry)
- Not yet recruiting
- Study type
- Interventional
- Enrollment
- 46 (estimated)
- First submitted
- 20 Sept 2026
- Start date
- 30 Sept 2026
- Primary completion date
- 31 Dec 2026
- Lead sponsor
- Kutahya Health Sciences University
- Diseases
- Coronary artery disease
- NCT number
- NCT07841847
What you commit to
- Study type: Interventional
- Planned participants: 46
- From 30 Sept 2026 to the primary completion date, 31 Dec 2026
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- History of orthopedic surgery within the previous 6 months
- Use of medications known to directly alter miRNA expression, such as certain immunosuppressive agents or chemotherapy drugs
Other illness
- Symptoms or signs of myocardial ischemia
- Ventricular arrhythmia
- Significant valvular heart disease
- Uncontrolled hypertension
- Severe comorbid conditions, including end-stage renal disease, advanced liver disease, or chronic inflammatory disease
- Active malignancy
- Physical limitations preventing full participation in exercise, including severe musculoskeletal disorders or major orthopedic or neurological comorbidities
- Failure to comply with exercise testing or training procedures, or attendance of less than 80% of the rehabilitation program
- Known psychiatric disorder
- Presence of a permanent cardiac pacemaker
Other
- Significant left ventricular outflow tract obstruction
- Body mass index greater than 35 kg/m²
Who the study is looking for
- Stable coronary artery disease
- History of percutaneous coronary intervention (PCI) or coronary artery bypass grafting (CABG)
- Referred and considered clinically eligible for a structured cardiac rehabilitation program
- Achievement of a respiratory quotient (RQ) of at least 1.0 during the baseline cardiopulmonary exercise test
- Ability and willingness to participate in the study and complete the cardiac rehabilitation program
Age in the registry: 35 years to 75 years · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Kütahya Health Sciences University Coordinator of this site? Confirm its status | Kütahya | Turkey (Türkiye) | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.