NCT07842991RecruitingPhase 3
Clinical Evaluation of a Toothpaste for Dental Plaque Reduction and Prevention of Gum Problems
Clinical Evaluation of a Stannous Fluoride Toothpaste Versus a 67% Bicarbonate Toothpaste and Colgate Cavity Protection Toothpaste for Dental Plaque Reduction and Prevention of Gum Problems: a Six-month Clinical Study in Italy
Source: ClinicalTrials.gov · Last updated 25 Sept 2026
Brief summary (registry, in English)
Qualified subjects will be enrolled and randomized to either one of the three study groups described above based on their initial modified gingivitis and plaque scores. Subjects will be instructed to use the products according to the instructions provided. Subjects will return to the dental office for evaluation after three months and six months of product use. All subjects will be followed for adverse events throughout the study.
- Status (registry)
- Recruiting
- Phase (registry)
- Phase 3
- Study type
- Interventional
- Enrollment
- 120 (estimated)
- First submitted
- 21 Sept 2026
- Start date
- 20 Jul 2026
- Primary completion date
- Jan 2027
- Lead sponsor
- Colgate Palmolive
- NCT number
- NCT07842991
What you commit to
- Study type: Interventional · Phase 3
- Planned participants: 120
- From 20 Jul 2026 to the primary completion date, Jan 2027
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Use of antibiotics any time during the one month prior to entry into the study.
- Participation in any other clinical study or test panel within the one month prior to entry into the study.
- Received a dental prophylaxis in the two weeks prior to your initial examination.
Other illness
- Advanced periodontal disease (purulent exudate, tooth mobility), and/or
- History of allergies to oral care/personal care consumer products or their ingredients.
- If you with an existing medical condition which prohibits you from not eating or drinking for periods of up to 4 hours.
- History of drug abuse
Other
- Orthodontic bands.
- Tumor(s) of the soft or hard tissues of the oral cavity.
- Extensive loss of periodontal attachment or alveolar bone.
- Five or more carious lesions requiring immediate restorative treatment
- Having taken any prescription medicines that might interfere with the study outcome.
- Self-reported pregnant or breast feeding an infant.
Who the study is looking for
- Subjects, ages 18-70, inclusive.
- Availability for the six-month duration of the study.
- Good general health.
- Initial gingivitis index of at least 1.5 as determined by the use of the Modified Gingivitis Index.
- Initial plaque index of at least 1.5 as determined by the use of the Modified Quigley-Hein Plaque Index.
- Signed Informed Consent Form
Age in the registry: 18 years to 70 years · Sex: All · Accepts healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Clinica Odontoiatrica Montesani Coordinator of this site? Confirm its status | Roma | Italy | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.