NCT07843212Recruiting
Effects of SPSIP Block on Perioperative Inflammation and TLR4 in Breast Cancer Surgery
Effects of Serratus Posterior Superior Intercostal Plane Block on Perioperative Inflammatory Response and TLR4-Mediated Innate Immune Activation in Breast Cancer Surgery: A Prospective, Randomized, Double-Blind, Sham-Controlled Trial
Source: ClinicalTrials.gov · Last updated 21 Oct 2026
Brief summary (registry, in English)
This study will investigate whether the serratus posterior superior intercostal plane (SPSIP) block improves postoperative recovery after breast cancer surgery. Participants will be randomly assigned to one of two groups. One group will receive an ultrasound-guided SPSIP block, while the other group will undergo a similar procedure without active medication (sham procedure). Both groups will receive standard general anesthesia and postoperative pain management. Postoperative pain intensity, need for additional pain medication, nausea and vomiting, length of hospital stay, and persistent pain at 3 months after surgery will be assessed. Blood samples collected before surgery and at predetermined postoperative time points will be used to evaluate the body's inflammatory response to surgery and innate immune system activity. These assessments will include toll-like receptor 4 (TLR4), an immune-system marker, and selected inflammatory markers. The main question of this study is whether the SPSIP block, compared with the sham procedure, reduces the surgery-related inflammatory response and improves postoperative pain outcomes.
- Status (registry)
- Recruiting
- Study type
- Interventional
- Enrollment
- 80 (estimated)
- First submitted
- 20 Sept 2026
- Start date
- 22 Jun 2026
- Primary completion date
- 30 Jan 2027
- Lead sponsor
- Mucahide Emine Fidancı Kuas
- NCT number
- NCT07843212
What you commit to
- Study type: Interventional
- Planned participants: 80
- From 22 Jun 2026 to the primary completion date, 30 Jan 2027
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Other illness
- Allergy or contraindication to the study local anesthetic.
- Infection at the planned injection site.
- Pre-existing chronic pain condition or regular opioid use.
Other
- Refusal to participate or inability to provide informed consent.
- Coagulopathy or ongoing anticoagulant treatment contraindicating regional anesthesia.
- Inability to communicate pain scores or comply with study assessments.
Who the study is looking for
- Female patients aged 18 to 85 years.
- Scheduled for elective breast cancer surgery under general anesthesia.
- American Society of Anesthesiologists (ASA) physical status I-III.
- Able to provide written informed consent.
Age in the registry: 18 years to 85 years · Sex: Female · Accepts healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Hitit University Erol Olcok Training and Research Hospital Coordinator of this site? Confirm its status | Çorum | Turkey (Türkiye) | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.