NCT07843459Not yet recruitingPhase 1
A Study of LY4560736 in Healthy Participants and Participants With Alzheimer's Disease (AD)
A Placebo-Controlled, Single- and Multiple-Ascending Dose, Phase 1 Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of LY4560736 in Healthy Participants and Participants With Alzheimer's Disease
Source: ClinicalTrials.gov · Last updated 8 Oct 2026
Brief summary (registry, in English)
The purpose of this study is to see how safe LY4560736 is and to see how much and how quickly LY4560736 gets into the bloodstream. For healthy participants, the study also looks at how much LY4560736 gets into the brain. This part of the study lasts up to 13 weeks which includes staying in the Clinical Research Unit (CRU) for at least 4 days. This group will include Japanese participants, and the Sponsor may choose to enroll Chinese participants. For participants with Alzheimer's Disease, the study will also look at levels of a specific Alzheimer's-related protein in the brain and will last up to 13 weeks which includes staying in the CRU twice, each lasts about 1 to 2 days. Japanese participants, and potentially Chinese participants, may also be enrolled in this group.
- Status (registry)
- Not yet recruiting
- Phase (registry)
- Phase 1
- Study type
- Interventional
- Enrollment
- 111 (estimated)
- First submitted
- 22 Sept 2026
- Start date
- Oct 2026
- Primary completion date
- Jul 2028
- Lead sponsor
- Eli Lilly and Company
- Diseases
- Alzheimer disease
- NCT number
- NCT07843459
What you commit to
- Study type: Interventional · Phase 1
- Planned participants: 111
- From Oct 2026 to the primary completion date, Jul 2028
- 18 sites in 3 countries
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Are receiving therapeutic antibodies or expected to initiate treatment with therapeutic antibodies during the study.
Other illness
- Have a condition that predisposes the participant to an infection.
- Have a current or recent acute, active infection.
- Have active tuberculosis (TB), have or have had latent TB.
Who the study is looking for
- Participants must meet eligibility criteria in the A1D-MC-ATMP screening protocol before entry into the treatment study.
- To qualify as a participant of first-generation Japanese origin, the participant, the participant's biological parents, and all the participant's biological grandparents must be of exclusive Japanese descent and born in Japan.
- To qualify as Chinese for this study, all four of the participant's biological grandparents must be of exclusive Chinese descent and born in China.
Age in the registry: 18 years to 85 years · Sex: All · Accepts healthy volunteers
Sites (18)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Xuanwu Hospital, Capital Medical University Coordinator of this site? Confirm its status | Beijing | China | Unknown status |
| Huashan Hospital, Fudan University Coordinator of this site? Confirm its status | Minhang District | China | Unknown status |
| Renji Hospital Affiliated to Shanghai Jiao Tong University School of Medicine Coordinator of this site? Confirm its status | Shanghai | China | Unknown status |
| The University of Tokyo Hospital Coordinator of this site? Confirm its status | Bunkyō City | Japan | Unknown status |
| National Center for Geriatrics and Gerontology Coordinator of this site? Confirm its status | Ōbu | Japan | Unknown status |
| CenExel ACT Coordinator of this site? Confirm its status | Anaheim | United States | Unknown status |
| Fortrea Clinical Research Unit Coordinator of this site? Confirm its status | Daytona Beach | United States | Unknown status |
| Accel Research Sites - NeuroStudies Clinical Research Unit Coordinator of this site? Confirm its status | Decatur | United States | Unknown status |
| QUEST Research Institute Coordinator of this site? Confirm its status | Farmington Hills | United States | Unknown status |
| Irvine Clinical Research Coordinator of this site? Confirm its status | Irvine | United States | Unknown status |
| K2 MEDICAL Research THE VILLAGES Coordinator of this site? Confirm its status | Lady Lake | United States | Unknown status |
| Collaborative Neuroscience Network - CNS Coordinator of this site? Confirm its status | Los Alamitos | United States | Unknown status |
| K2 Medical Research Coordinator of this site? Confirm its status | Maitland | United States | Unknown status |
| Charter Research Coordinator of this site? Confirm its status | Orlando | United States | Unknown status |
| Progressive Medical Research Coordinator of this site? Confirm its status | Port Orange | United States | Unknown status |
| Alzheimer's Research and Treatment Center Coordinator of this site? Confirm its status | Stuart | United States | Unknown status |
| K2 Medical Research - Tampa Coordinator of this site? Confirm its status | Tampa | United States | Unknown status |
| Charter Research Coordinator of this site? Confirm its status | The Villages | United States | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.