Fact CheckerSign in

NCT07843459Not yet recruitingPhase 1

A Study of LY4560736 in Healthy Participants and Participants With Alzheimer's Disease (AD)

A Placebo-Controlled, Single- and Multiple-Ascending Dose, Phase 1 Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of LY4560736 in Healthy Participants and Participants With Alzheimer's Disease

Source: ClinicalTrials.gov · Last updated 8 Oct 2026

Brief summary (registry, in English)

The purpose of this study is to see how safe LY4560736 is and to see how much and how quickly LY4560736 gets into the bloodstream. For healthy participants, the study also looks at how much LY4560736 gets into the brain. This part of the study lasts up to 13 weeks which includes staying in the Clinical Research Unit (CRU) for at least 4 days. This group will include Japanese participants, and the Sponsor may choose to enroll Chinese participants. For participants with Alzheimer's Disease, the study will also look at levels of a specific Alzheimer's-related protein in the brain and will last up to 13 weeks which includes staying in the CRU twice, each lasts about 1 to 2 days. Japanese participants, and potentially Chinese participants, may also be enrolled in this group.

Status (registry)
Not yet recruiting
Phase (registry)
Phase 1
Study type
Interventional
Enrollment
111 (estimated)
First submitted
22 Sept 2026
Start date
Oct 2026
Primary completion date
Jul 2028
Lead sponsor
Eli Lilly and Company
NCT number
NCT07843459

What you commit to

  • Study type: Interventional · Phase 1
  • Planned participants: 111
  • From Oct 2026 to the primary completion date, Jul 2028
  • 18 sites in 3 countries
  • Visits and tests: ask the trial team, the registry does not list them

Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.

Who cannot take part

Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.

Prior treatment

  • Are receiving therapeutic antibodies or expected to initiate treatment with therapeutic antibodies during the study.

Other illness

  • Have a condition that predisposes the participant to an infection.
  • Have a current or recent acute, active infection.
  • Have active tuberculosis (TB), have or have had latent TB.

Who the study is looking for

  • Participants must meet eligibility criteria in the A1D-MC-ATMP screening protocol before entry into the treatment study.
  • To qualify as a participant of first-generation Japanese origin, the participant, the participant's biological parents, and all the participant's biological grandparents must be of exclusive Japanese descent and born in Japan.
  • To qualify as Chinese for this study, all four of the participant's biological grandparents must be of exclusive Chinese descent and born in China.

Age in the registry: 18 years to 85 years · Sex: All · Accepts healthy volunteers

Full criteria on ClinicalTrials.gov

Sites (18)

Sites in registry order. Pick your city on the disease page to sort them by distance.

SiteCityCountrySite status
Xuanwu Hospital, Capital Medical University
Coordinator of this site? Confirm its status
BeijingChinaUnknown status
Huashan Hospital, Fudan University
Coordinator of this site? Confirm its status
Minhang DistrictChinaUnknown status
Renji Hospital Affiliated to Shanghai Jiao Tong University School of Medicine
Coordinator of this site? Confirm its status
ShanghaiChinaUnknown status
The University of Tokyo Hospital
Coordinator of this site? Confirm its status
Bunkyō CityJapanUnknown status
National Center for Geriatrics and Gerontology
Coordinator of this site? Confirm its status
ŌbuJapanUnknown status
CenExel ACT
Coordinator of this site? Confirm its status
AnaheimUnited StatesUnknown status
Fortrea Clinical Research Unit
Coordinator of this site? Confirm its status
Daytona BeachUnited StatesUnknown status
Accel Research Sites - NeuroStudies Clinical Research Unit
Coordinator of this site? Confirm its status
DecaturUnited StatesUnknown status
QUEST Research Institute
Coordinator of this site? Confirm its status
Farmington HillsUnited StatesUnknown status
Irvine Clinical Research
Coordinator of this site? Confirm its status
IrvineUnited StatesUnknown status
K2 MEDICAL Research THE VILLAGES
Coordinator of this site? Confirm its status
Lady LakeUnited StatesUnknown status
Collaborative Neuroscience Network - CNS
Coordinator of this site? Confirm its status
Los AlamitosUnited StatesUnknown status
K2 Medical Research
Coordinator of this site? Confirm its status
MaitlandUnited StatesUnknown status
Charter Research
Coordinator of this site? Confirm its status
OrlandoUnited StatesUnknown status
Progressive Medical Research
Coordinator of this site? Confirm its status
Port OrangeUnited StatesUnknown status
Alzheimer's Research and Treatment Center
Coordinator of this site? Confirm its status
StuartUnited StatesUnknown status
K2 Medical Research - Tampa
Coordinator of this site? Confirm its status
TampaUnited StatesUnknown status
Charter Research
Coordinator of this site? Confirm its status
The VillagesUnited StatesUnknown status

This page is information, not medical advice. Discuss any trial with your doctor.