NCT07843472RecruitingPhase 3
A Phase III Study to Evaluate the Efficacy and Safety of Petrelintide in Participants With Overweight or Obesity and Established Cardiovascular Disease
A Phase III, Randomized, Double-Blind, Placebo Controlled, Parallel Group Study to Evaluate the Efficacy and Safety of Once Weekly Petrelintide Vs. Placebo in Participants With Overweight Or Obesity And Established Cardiovascular Disease
Source: ClinicalTrials.gov · Last updated 7 Oct 2026
Brief summary (registry, in English)
This study will evaluate the efficacy and safety of petrelintide compared with placebo, in conjunction with a reduced-calorie diet and increased physical activity, for weight management in participants living with overweight or obesity and established cardiovascular disease (CVD).
- Status (registry)
- Recruiting
- Phase (registry)
- Phase 3
- Study type
- Interventional
- Enrollment
- 2500 (estimated)
- First submitted
- 22 Sept 2026
- Start date
- 30 Sept 2026
- Primary completion date
- 28 Jul 2030
- Lead sponsor
- Hoffmann-La Roche
- Diseases
- Obesity
- NCT number
- NCT07843472
- EU CT number
- 2026-526190-41-00
What you commit to
- Study type: Interventional · Phase 3
- Planned participants: 2500
- From 30 Sept 2026 to the primary completion date, 28 Jul 2030
- 3 sites in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Current or previous treatment with petrelintide or any other amylin analog
Other illness
- Known history of Type 1 diabetes mellitus
Who the study is looking for
- Participants with BMI ≥ 27 kg/m² and established CVD
- History of at least one self-reported unsuccessful dietary effort to lose body weight
Age in the registry: 40 years to - · Sex: All · Does not accept healthy volunteers
Sites (3)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Pinnacle Research Group Coordinator of this site? Confirm its status | Anniston | United States | Recruiting |
| Institute for Metabolic Research Los Angeles Coordinator of this site? Confirm its status | Los Angeles | United States | Recruiting |
| Progressive Medical Research Coordinator of this site? Confirm its status | Port Orange | United States | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.