NCT07843498RecruitingPhase 3
A Phase III Study to Evaluate the Efficacy and Safety of Petrelintide in Participants With Overweight or Obesity
A Phase III, Randomized, Double-Blind, Placebo-Controlled, Parallel Group Study to Evaluate the Efficacy and Safety of Once Weekly Petrelintide vs. Placebo in Participants With Overweight or Obesity
Source: ClinicalTrials.gov · Last updated 7 Oct 2026
Brief summary (registry, in English)
This study will evaluate the efficacy and safety of petrelintide compared with placebo, in conjunction with a reduced-calorie diet and increased physical activity, for weight management in participants living with overweight or obesity, at least one weight-related comorbidity, and without Type 2 Diabetes (T2D).
- Status (registry)
- Recruiting
- Phase (registry)
- Phase 3
- Study type
- Interventional
- Enrollment
- 3900 (estimated)
- First submitted
- 11 Sept 2026
- Start date
- 30 Sept 2026
- Primary completion date
- 21 Dec 2028
- Lead sponsor
- Hoffmann-La Roche
- Diseases
- Obesity
- NCT number
- NCT07843498
- EU CT number
- 2026-526188-39-00
What you commit to
- Study type: Interventional · Phase 3
- Planned participants: 3900
- From 30 Sept 2026 to the primary completion date, 21 Dec 2028
- 3 sites in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Current or previous treatment with petrelintide or any other amylin analog
Other illness
- Known history of Type 1 or Type 2 diabetes mellitus
Lab values
- HbA1c ≥ 48 mmol/mol (6.5%), measured by the central laboratory at screening
Who the study is looking for
- Participants with BMI ≥ 30 kg/m² or BMI ≥ 27 kg/m² with at least one weight-related comorbidity
- History of at least one self-reported unsuccessful dietary effort to lose body weight
Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers
Sites (3)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Pinnacle Research Group Coordinator of this site? Confirm its status | Anniston | United States | Recruiting |
| Clinical Research Associates Coordinator of this site? Confirm its status | Nashville | United States | Recruiting |
| Progressive Medical Research Coordinator of this site? Confirm its status | Port Orange | United States | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.