NCT07846007Recruiting
Effects of Excitatory and Inhibitory LIFUS of GPi in Parkinsonian Patients Without DBS
Source: ClinicalTrials.gov · Last updated 29 Sept 2026
Brief summary (registry, in English)
Low intensity focused ultrasound (LIFUS) is a novel non-invasive brain stimulation (NIBS) technique that permits stimulation with high spatial focality and can reach greater depth compared other methods. This study will look at the effects of two different LIFUS stimulations on task performance in patients with Parkinson's disease. The effects of real stimulation will also be compared to sham stimulation. The evaluations will include behavioral tasks on the computer, the Unified Parkinson's Disease Rating Scale (UPDRS) motor scoring, and finger accelerometry recordings. These will be done before the LIFUS simulations and repeated after. This is to evaluate the different mechanisms and efficacy of these stimulations on deep brain areas.
- Status (registry)
- Recruiting
- Study type
- Interventional
- Enrollment
- 15 (estimated)
- First submitted
- 22 Feb 2026
- Start date
- 14 Feb 2024
- Primary completion date
- Dec 2027
- Lead sponsor
- University Health Network, Toronto
- Diseases
- Parkinson disease
- NCT number
- NCT07846007
What you commit to
- Study type: Interventional
- Planned participants: 15
- From 14 Feb 2024 to the primary completion date, Dec 2027
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Has intracranial implant(s) or device(s)
- Has a previous surgical intervention to treat the movement disorder such as lesioning or a Deep Brain Stimulation system in place.
- Is on antipsychotics, anti-depressants, marijuana, or other recreational drugs that affect the nervous system
Other illness
- History of stroke or seizure
- Comorbid dementia
- Has an implanted cardiac pacemaker or implantable cardioverter-defibrillator (ICD)
- Major depression/psychiatric disorder that in the opinion of the Investigator will affect patient's understanding of study procedures and willingness to abide by all procedures during the course of the study
- Major musculoskeletal or neuromuscular disease or disorder of the hands, wrists and limbs
- Major systemic illness or infection
Other
- Scored below 22 on the Montreal Cognitive Assessment (MoCA)
- Presence of metal implanted in body that is contraindicated in TMS/MRI/peripheral electrical stimulation
- Pregnancy
- Severe Dyskinesia
Who the study is looking for
- 18-90 years of age
- Confirmed diagnosis of Parkinson's disease
- Stable dopaminergic medication dose for a minimum of 4 weeks
Age in the registry: 18 years to 90 years · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Toronto Western Hospital Coordinator of this site? Confirm its status | Toronto | Canada | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.