NCT07847853Not yet recruiting
Inductive Therapeutic Exercise in Multiple Sclerosis
Effects of Inductive Therapeutic Exercise on Muscle Tone, Postural Control, and Quality of Life in Patients With Multiple Sclerosis.
Source: ClinicalTrials.gov · Last updated 2 Oct 2026
Brief summary (registry, in English)
ETOTUR is a research project comprising two complementary stages. The first is an observational study in approximately 50 healthy adults to develop and validate a mobile tool for quantitative assessment of muscle tone using the pendulum test. Measurements obtained with the mobile tool will be compared with laboratory reference systems, and preliminary reference values will be established. The second stage, which is the focus of this clinical trial registration, is a pilot controlled study involving approximately 30 adults with multiple sclerosis and altered muscle tone and standing postural control. Participants will receive either Inductive Therapeutic Exercise (ETI, from the Spanish "Ejercicio Terapéutico Inductivo") or Sham Inductive Therapeutic Exercise (sham-ETI), a simulated intervention, with one individual session of approximately 40 minutes per week for 8 weeks. ETI combines specific active movements and breathing patterns intended to elicit involuntary neuromuscular responses in other body regions. Sham-ETI uses similar movements while omitting the principal movement and breathing components intended to produce induction. Participants will be assigned using a nonrandom sequential balancing procedure based on relevant baseline characteristics. Outcome assessment will be performed by a physiotherapist blinded to group allocation. Outcomes will be assessed at baseline, immediately after the 8-week intervention, and approximately one month later. The main outcomes are lower-limb muscle tone assessed using the pendulum test, standing postural control measured with a pressure platform, and health-related quality of life assessed with the Multiple Sclerosis Quality of Life-54 questionnaire (MSQoL-54). Adherence, tolerability, and intervention-related clinical incidents will also be recorded. The study will explore whether changes following ETI differ from those observed after sham-ETI and will provide preliminary information to support the design of subsequent confirmatory research.
- Status (registry)
- Not yet recruiting
- Study type
- Interventional
- Enrollment
- 30 (estimated)
- First submitted
- 22 Sept 2026
- Start date
- 1 Oct 2027
- Primary completion date
- 31 Jul 2028
- Lead sponsor
- Fundación San Juan De Dios
- Diseases
- Multiple sclerosis
- NCT number
- NCT07847853
What you commit to
- Study type: Interventional
- Planned participants: 30
- From 1 Oct 2027 to the primary completion date, 31 Jul 2028
- 2 sites in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Receipt of inductive therapies, neuromodulatory treatments, or specific interventions targeting muscle tone during the previous 6 months.
Other illness
- Other neurological, neurodegenerative, or musculoskeletal conditions that may interfere with biomechanical or functional assessments.
- Uncontrolled arterial hypertension or ocular hypertension.
Other
- Insufficient understanding of Spanish or inability to follow the study instructions.
- Medical contraindication to the proposed interventions or assessments.
- An acute multiple sclerosis exacerbation or clinical relapse in the months preceding study entry, as determined by medical judgment.
- Pregnancy.
- Inability to maintain sitting or standing for the duration required to complete the biomechanical assessments.
Who the study is looking for
- Confirmed medical diagnosis of multiple sclerosis.
- Age 18 years or older.
- Ability to understand and follow the instructions required for the study procedures.
- Altered lower-limb muscle tone, demonstrated by pendulum test measurements outside the reference ranges established in the preparatory study and/or normative values reported in the scientific literature.
- Impaired standing postural control, demonstrated by stabilometric parameters consistent with reduced postural stability, such as increased center of pressure displacement, increased mean sway velocity, or increased sway area.
- Provision of written informed consent.
Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers
Sites (2)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Hospital Universitario San Rafael Coordinator of this site? Confirm its status | Madrid | Spain | Unknown status |
| Escuela Universitaria de Enfermería y Fisioterapia San Juan de Dios - Universidad Pontificia Comillas Coordinator of this site? Confirm its status | Madrid | Spain | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.