NCT07848815Recruiting
Risk-Based Lung Cancer Detection in COPD Patients
Early Lung Cancer Detection in High-Risk Patients With Risk-Based Machine Learning Models and Biomarkers
Source: ClinicalTrials.gov · Last updated 30 Sept 2026
Brief summary (registry, in English)
The goal of the interventional study is to evaluate whether risk-based stratification using the PLCOm2012 model and a machine learning (ML) model can identify patients with chronic obstructive pulmonary disease (COPD) who are at high risk of developing lung cancer and may benefit from low-dose computed tomography (LDCT) screening. The study population includes adults aged 50 years and older with COPD and a history of smoking attending an outpatient clinic. The main question it aims to answer are: \- What is the incidence of histopathologically confirmed lung cancer following risk-based stratification? Participants will: * Undergo lung cancer risk assessment using the PLCOm2012 model and an ML-based model based on clinical and laboratory data * Be referred for LDCT if classified as high-risk * Continue standard care if classified as low-risk * Be followed through electronic health records for up to six years to assess outcomes including lung cancer incidence, adherence to LDCT, time to imaging, healthcare utilization, costs, and safety
- Status (registry)
- Recruiting
- Study type
- Interventional
- Enrollment
- 1000 (estimated)
- First submitted
- 23 Sept 2026
- Start date
- Jun 2026
- Primary completion date
- Dec 2027
- Lead sponsor
- Vejle Hospital
- Diseases
- COPD, Lung cancer
- NCT number
- NCT07848815
What you commit to
- Study type: Interventional
- Planned participants: 1000
- From Jun 2026 to the primary completion date, Dec 2027
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Previous diagnosis of lung cancer within the last five years.
Other illness
- Active treatment for cancer within the last 12 months except non-melanoma skin cancer and carcinoma in situ cervicis uteri.
- Invasive methods to verify potential lung cancer not an option.
Other
- Inability to provide informed consent.
Who the study is looking for
- Diagnosed with COPD
- Age ≥ 50 years
- Attendance at the outpatient Respiratory Medicine clinic, Vejle Hospital, University Hospital of Southern Denmark
- Smoking history (current or former smoker)
- Consent to translational research and biobank.
Age in the registry: 50 years to - · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Vejle Hospital, University Hospital of Southern Denmark Coordinator of this site? Confirm its status | Vejle | Denmark | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.