NCT07848919Completed
Combined tDCS and Cognitive Neurorehabilitation in Post-Stroke Depression
Multimodal Intervention Using Transcranial Direct Current Stimulation (tDCS) and Cognitive Neurorehabilitation to Reduce Affective Symptoms in Ischemic Stroke Patients With Mild-to-moderate Sequelae
Source: ClinicalTrials.gov · Last updated 30 Sept 2026
Brief summary (registry, in English)
This study evaluates a multimodal intervention pathway for affective and cognitive symptoms after ischemic stroke. Patients undergo an initial screening of depressive symptoms, cognitive function, and quality of life. Participants meeting the criteria for intervention are randomized to one of four groups: active transcranial direct current stimulation (tDCS), sham tDCS, online cognitive neurorehabilitation, or a combined intervention using active tDCS and online cognitive neurorehabilitation. Clinical outcomes include depressive symptoms, cognitive performance, and quality of life assessed longitudinally during follow-up.
- Status (registry)
- Completed
- Study type
- Interventional
- Enrollment
- 33 (actual)
- First submitted
- 18 Sept 2026
- Start date
- 9 Apr 2024
- Primary completion date
- 17 Apr 2026
- Lead sponsor
- Institut de Recerca Biomèdica de Lleida-Fundació Dr. Pifarré (IRBLleida)
- Diseases
- Stroke
- NCT number
- NCT07848919
What you commit to
- Study type: Interventional
- Participants enrolled: 33
- From 9 Apr 2024 to the primary completion date, 17 Apr 2026
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Electrically, mechanically, or magnetically activated implants.
Other illness
- Severe pre-existing psychiatric disorder
- Active diagnosed depression at the time of stroke
- Pre-existing cognitive impairment
- History of alcoholism or substance abuse
- History of seizures.
- Unexplained episodes of loss of consciousness potentially related to epilepsy or other cerebral disorders.
- Uncontrolled or unstable neuropsychiatric disorder.
- Cardiac pacemaker.
- Cardiac, neural, or drug-delivery implants.
- Dermatological conditions affecting the stimulation site, including dermatitis, psoriasis, or eczema.
- Severe life-threatening medical conditions, including congestive heart failure, chronic obstructive pulmonary disease, or active malignancy.
Other
- Transient ischemic attack (TIA)
- Language barrier preventing adequate understanding Catalan or Spanish
- Severe aphasia, defined as a score ≥2 on item 9 and/or 10 of the NIHSS
- Life expectancy \<12 months
- Implanted medical devices in the brain.
- Vascular clips.
- Severe brain lesions.
- Skin lesions at the stimulation site
- Frequent or severe headaches.
- Pregnancy
Who the study is looking for
- Age 18-80 years
- Acute ischemic stroke confirmed by neuroimaging
- Modified Rankin Scale (mRS) score ≤3 at discharge
- NIH Stroke Scale (NIHSS) score ≤8 at discharge
- Time from symptom onset to inclusion \<15 days
- Time from ischemic stroke symptom onset to first neurological care \<48 hours
Age in the registry: 18 years to 80 years · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Hospital Universitari Arnau de Vilanova Coordinator of this site? Confirm its status | Lleida | Spain | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.