NCT07852065Active, not recruiting
iTBS Versus Standard 10 Hz rTMS for Treatment-Resistant Depression (TRD)
A Randomised Controlled Non-Inferiority Study Comparing Efficacy of Intermittent Theta Burst Stimulation Versus Standard 10HZ Repetitive Transcranial Magnetic Stimulation In Treatment-Resistant Depression Patients
Source: ClinicalTrials.gov · Last updated 1 Oct 2026
Brief summary (registry, in English)
This randomised, parallel-group, non-inferiority trial compared intermittent theta burst stimulation (iTBS, 3-minute sessions) with standard 10 Hz repetitive transcranial magnetic stimulation (rTMS, 37-minute sessions) applied to the left dorsolateral prefrontal cortex (DLPFC) in adults with treatment-resistant depression (TRD). Participants received 20 sessions over 4 weeks. The primary aim was to determine whether iTBS is non-inferior to standard rTMS in reducing depressive symptoms (HDRS-17) at Week 4, and to compare patient-reported treatment experience and acceptability between protocols.
- Status (registry)
- Active, not recruiting
- Study type
- Interventional
- Enrollment
- 182 (estimated)
- First submitted
- 21 Sept 2026
- Start date
- Jun 2026
- Primary completion date
- Jan 2027
- Lead sponsor
- Kafrelsheikh University
- Diseases
- Depression
- NCT number
- NCT07852065
What you commit to
- Study type: Interventional
- Planned participants: 182
- From Jun 2026 to the primary completion date, Jan 2027
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Other illness
- ● Current major depressive episode in the context of bipolar disorder
- MDD with psychotic features
- Primary psychotic disorder
- History of traumatic brain injury or brain lesions
Who the study is looking for
- ● Adults aged 18-65 years, both sexes
- Meets DSM-5 criteria for major depressive disorder, confirmed by SCID-5
- Treatment-resistant depression: failure to achieve adequate response after ≥2 adequate antidepressant trials (adequate dose, duration, and adherence)
Age in the registry: 18 years to 65 years · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| : Kafr-Elsheikh Outpatient Psychiatric Clinic, Egypt; Menoufia Outpatient Psychiatric Clinic, Egypt Coordinator of this site? Confirm its status | Kafr ash Shaykh | Egypt | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.