NCT07852156Recruiting

Cooling During Inpatient Rehabilitation in Persons With MS

Optimizing Inpatient Rehabilitation - Investigating the Effects of Cooling During Intensive Active Training Sessions on Fatigue in Persons With Multiple Sclerosis

Source: ClinicalTrials.gov · Last updated 1 Oct 2026

Brief summary (registry, in English)

The goal of this clinical trial is to shed light on the use of cooling during intensive active training sessions during a three-week multidisciplinary inpatient rehabilitation stay in persons with Multiple Sclerosis. The objectives of this study are: * to investigate the effects of one week of using a cooling vest during intensive active training sessions compared with one week of not using a cooling vest during inpatient rehabilitation on the state fatigue in persons with Multiple Sclerosis. * to investigate the effects of one week of using a cooling vest during intensive active training sessions compared with one week of not using a cooling vest during inpatient rehabilitation on the walking capacity, functional lower limb muscle strength, balance and cognition in persons with Multiple Sclerosis. * to investigate the effects of the three-week inpatient rehabilitation on the cardiorespiratory fitness, muscle strength and trait fatigue in persons with Multiple Sclerosis. Researchers will compare the effects of one week of using a cooling vest during intensive active training sessions with one week of not using a cooling vest during intensive active training sessions during three weeks of inpatient rehabilitation. Participants will * Wear a cooling vest during intensive active training sessions for one week * Attend the assessment appointments during study participation * Keep a diary recording their use of a cooling vest during intensive active training sessions

Status (registry): Recruiting
Study type: Interventional
Enrollment: 42 (estimated)
First submitted: 16 Sept 2026
Start date: 28 Jul 2026
Primary completion date: 1 Sept 2028
Lead sponsor: Klinik Valens
Diseases: Multiple sclerosis
NCT number: NCT07852156

What you commit to

Study type: Interventional
Planned participants: 42
From 28 Jul 2026 to the primary completion date, 1 Sept 2028
1 site in 1 country
Visits and tests: ask the trial team, the registry does not list them

Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.

Who cannot take part

Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.

Prior treatment

Severe concomitant disease states (i.e. orthopaedic, cardiovascular, metabolic, psychiatric (e.g., substance abuse), other neurological disease states, other serious medical conditions) impairing the ability to participate;
Previous enrolment into this study;

Other illness

Cognitive impairment (Montreal Cognitive Assessment, MoCA score \< 26);
Sudden severe disease progression or falling sick (e.g. bacterial or viral infections) during the study;

Other

Inability to follow the study procedures (i.e. participant not fluent in oral and written German language);
Participation in another study;
Pregnant or lactating women;
Intention to become pregnant during this study;
Suspected non-compliance;
Subjective perceived cold sensitivity (Yes).

Who the study is looking for

FSMC total score ≥ 43;
Adult age (≥ 18 years);
A definite MS diagnosis according to the 2024 revised McDonald criteria with relapsing-remitting, primary or secondary progressive phenotypes;
Disease severity according to Expanded disability status scale (EDSS) score 3.0-6.0;
Subjective perceived heat sensitivity (Yes).

Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers

Full criteria on ClinicalTrials.gov

Sites (1)

Sites in registry order. Pick your city on the disease page to sort them by distance.

Site	City	Country	Site status
Rehabilitation clinic Valens Coordinator of this site? Confirm its status	Valens	Switzerland	Recruiting

This page is information, not medical advice. Discuss any trial with your doctor.