NCT07854210Recruiting
HFNC Versus NIV in Hypercapneic COPD Patients
Gas Exchange, Clinical Outcomes, and Tolerability of High-Flow Nasal Cannula Versus Non-Invasive Ventilation in COPD Patients With Mild-to-Moderate Hypercapnic Respiratory Failure
Source: ClinicalTrials.gov · Last updated 2 Oct 2026
Brief summary (registry, in English)
Aim: To compare gas exchange trends, clinical outcomes, and tolerability between HFNC and NIV in COPD patients with mild-to-moderate hypercapnic respiratory failure.
- Status (registry)
- Recruiting
- Study type
- Interventional
- Enrollment
- 70 (estimated)
- First submitted
- 19 Sept 2026
- Start date
- 3 Nov 2025
- Primary completion date
- Nov 2026
- Lead sponsor
- Mohammed Shehta
- Diseases
- COPD
- NCT number
- NCT07854210
What you commit to
- Study type: Interventional
- Planned participants: 70
- From 3 Nov 2025 to the primary completion date, Nov 2026
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- patients with altered mental state, confused, severe agitation or not cooperative were excluded. Also, severe acidosis (pH \<7.25), hemodynamic instability, facial trauma or surgery, cases with severe nasal deformity, immediate indication for invasive ventilation, patient refusal, cases with respiratory rate more than 35 breaths per minute. Respiratory exhaustion, excess use of respiratory accessory muscles, Patients with breathing disorders during sleep as well as cases of upper airway obstruction and patients with history of chronic home ventilation prior admission were another items for exclusion
Who the study is looking for
- COPD patients hospitalized with mild-to-moderate hypercapnic respiratory failure, defined as arterial pH \[range, e.g., 7.25-7.35\] and PaCO2 \[threshold, e.g., \>45 mmHg and less 60 mmHg\].
Age in the registry: 40 years to - · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Faculty of Medicine, Mansoura University Coordinator of this site? Confirm its status | Al Mansurah | Egypt | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.