NCT07855367Recruiting
Cryoneurolysis Versus Bipolar Radiofrequency Ablation of Genicular Nerves for Pain Relief in Symptomatic Knee Osteoarthritis
Ultrasound-Guided Cryoneurolysis Versus Bipolar Radiofrequency Ablation of Genicular Nerves for Pain Relief in Symptomatic Knee Osteoarthritis: A Randomized Controlled Trial
Source: ClinicalTrials.gov · Last updated 2 Oct 2026
Brief summary (registry, in English)
This study aims to compare the reduction in knee pain between ultrasound-guided cryoneurolysis and bipolar radiofrequency ablation (RFA), as measured by the Numerical Rating Scale (NRS) at predefined follow-up intervals.
- Status (registry)
- Recruiting
- Study type
- Interventional
- Enrollment
- 30 (estimated)
- First submitted
- 28 Sept 2026
- Start date
- 15 Sept 2026
- Primary completion date
- 15 Mar 2027
- Lead sponsor
- National Cancer Institute, Egypt
- NCT number
- NCT07855367
What you commit to
- Study type: Interventional
- Planned participants: 30
- From 15 Sept 2026 to the primary completion date, 15 Mar 2027
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Prior genicular nerve ablation
Other illness
- Local infection
- Neuropathic pain syndromes
Other
- Coagulopathy
- Severe deformity
- Uncontrolled comorbidities
Who the study is looking for
- Age ≥ 40 years
- Symptomatic knee osteoarthritis (OA) in bladder cancer patient \[based on American College of Radiology (ACR) criteria\]
- Radiological OA (Kellgren-Lawrence grade III-IV)
- Chronic knee pain ≥ 3-6 months
- Numerical Rating Scale (NRS) ≥ 5 despite conservative treatment
- Positive diagnostic genicular nerve block (\>50% pain relief).
Age in the registry: 40 years to - · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Cairo University Coordinator of this site? Confirm its status | Cairo | Egypt | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.