NCT07855939Recruiting
Long-term Iron Absorption and Loss in Women
Long-term Iron Absorption and Loss in Overweight/Obese Thai Middle-aged Women
Source: ClinicalTrials.gov · Last updated 2 Oct 2026
Brief summary (registry, in English)
Obese people typically have chronic low-grade inflammation. Based on short-term studies, this inflammation could affect the absorption, utilization, storage, and mobilization of iron, and individuals with inflammation might develop iron deficiency (ID) and anemia when inadequacy of iron intake is presented. The double burden of malnutrition is nowadays emerging as a major public health concern in many countries, including Thailand. Understanding the association of chronic inflammation among people with overweight or obesity (OW/OB) with long-term iron absorption and loss is important for developing appropriate policies and programs to promote iron balance and, consequently, optimal iron status and health outcomes. Since previous reports among Thai women showed a high prevalence of OW/OB and anemia, this study will be conducted to determine the long-term iron absorption and loss among OW/OB free-living women using the iron isotope dilution method.
- Status (registry)
- Recruiting
- Study type
- Observational
- Enrollment
- 64 (estimated)
- First submitted
- 6 Aug 2026
- Start date
- 8 May 2025
- Primary completion date
- 31 Dec 2027
- Lead sponsor
- Mahidol University
- Diseases
- Obesity
- NCT number
- NCT07855939
What you commit to
- Study type: Observational
- Planned participants: 64
- From 8 May 2025 to the primary completion date, 31 Dec 2027
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Normal weight group
- Having serious medical conditions such as cancer, chronic kidney disease, chronic liver disease, or chronic heart failure
- Having metabolic NCDs (e.g., diabetes, hyperlipidemia, hypertension) requiring hospitalization
- Pregnant, breastfeeding, or planning pregnancy during the study
- Chronic infectious disease (e.g., tuberculosis, AIDS)
- Regular use of anti-inflammatory or other medications (except contraceptives and acne medication)
- Taking vitamin or mineral supplements during or within two weeks prior to the study
- Participating in a weight-loss program
- Known intolerance to iron supplements (e.g., vomiting, diarrhea, abdominal pain, bloating, nausea, or allergic reactions such as rash, breathing difficulty, chest tightness, facial or lip swelling)
- Blood transfusion, blood donation, or significant blood loss during the study or within 6 months before enrollment
- Heavy menstrual bleeding (\>80 mL/day, calculated from menstrual record)
- Overweight/obese group
- Obesity class II (BMI ≥35.0 kg/m²) with high health risk
- Having serious medical conditions such as cancer, chronic kidney disease, chronic liver disease, or chronic heart failure
- Having metabolic noncommunicable diseases (e.g., diabetes, hyperlipidemia, hypertension) requiring hospitalization
- Pregnant, breastfeeding, or planning pregnancy during the study
- Chronic infectious disease (e.g., tuberculosis, AIDS)
- Regular use of anti-inflammatory or other medications (except contraceptives and acne medication)
- Taking vitamin or mineral supplements during or within two weeks prior to the study
- Participating in a weight-loss program
- Known intolerance to iron supplements (e.g., vomiting, diarrhea, abdominal pain, bloating, nausea, or allergic reactions such as rash, breathing difficulty, chest tightness, facial or lip swelling)
- Blood transfusion, blood donation, or significant blood loss during the study or within 6 months before enrollment
- Heavy menstrual bleeding (\>80 mL/day, calculated from menstrual record)
Who the study is looking for
- Normal weight group
- Aged 40-50 years
- Normal weight (BMI 18.5-22.9 kg/m²)
- Hb ≥12.0 g/dL and inflammation-adjusted SFa \<50.0 µg/L
- CRP \<5.0 mg/L
- Normal hemoglobin typing
- Plans to reside in the study area for \>2 years
- Overweight/obese group
- Aged 40-50 years
- Overweight or obese \[Body Mass Index (BMI) ≥25.0 kg/m²\] - the BMI cut-off follows the agreement of countries under the Coordinated Research Project (CRP) E43038 "Using the iron isotope dilution technique to assess the influence of inflammation on long-term iron absorption and loss," supported by the IAEA
- Hemoglobin (Hb) ≥12.0 g/dL and inflammation-adjusted serum ferritin (SFa) \<50.0 µg/L
- C-reactive protein (CRP) between 5.0-25.0 mg/L
- Normal hemoglobin typing
- Plans to reside in the study area for \>2 years
Age in the registry: 40 years to 50 years · Sex: Female · Accepts healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Institute of Nutrition Coordinator of this site? Confirm its status | Nakhon Pathom | Thailand | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.