NCT07857096Not yet recruiting
Rehabilitation Through Individualized Support and Exercise
Feasibility and Compliance of a Tailored Physiotherapy Program for Early Mobilization After Oral Cancer Surgery
Source: ClinicalTrials.gov · Last updated 5 Oct 2026
Brief summary (registry, in English)
Oral cancer, the most prevalent form of head and neck malignancy, represents a major global health burden, with over 370,000 new cases annually according to the World Health Organization. Surgical resection with free flap reconstruction remains the gold standard for curative treatment, yet it often entails significant functional and physical impairment. The surgical procedure often involves tumor resection and reconstruction. Postoperative complications such as dysphagia, reduced masticatory function, and prolonged immobility frequently contribute to fatigue, loss of muscle mass, and delayed recovery, ultimately impacting quality of life and overall prognosis. Loss of skeletal muscle mass, commonly observed in this patient population, is strongly associated with impaired physical performance, reduced treatment tolerance, and increased postoperative morbidity. Recent evidence underscores that early mobilization and structured physiotherapeutic interventions can mitigate these effects, enhance functional recovery, and reduce length of hospital stay across various surgical populations. In head and neck cancer specifically, early mobilization has been associated with shorter hospitalization and fewer complications, yet practical, standardized physiotherapy protocols remain scarce and poorly defined. Despite inclusion of early mobilization principles in Enhanced Recovery After Surgery (ERAS) pathways, current head and neck cancer guidelines lack specific recommendations regarding the timing, intensity, and content of postoperative physical activity. Furthermore, evidence on patient compliance and feasibility of such interventions during the acute hospitalization phase is limited.
- Status (registry)
- Not yet recruiting
- Study type
- Interventional
- Enrollment
- 39 (estimated)
- First submitted
- 5 Aug 2026
- Start date
- 10 Sept 2026
- Primary completion date
- 1 Jan 2029
- Lead sponsor
- Universitaire Ziekenhuizen KU Leuven
- Diseases
- Head and neck cancer
- NCT number
- NCT07857096
What you commit to
- Study type: Interventional
- Planned participants: 39
- From 10 Sept 2026 to the primary completion date, 1 Jan 2029
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Other illness
- Severe psychiatric or neurocognitive impairment (e.g., dementia, Korsakoff syndrome, schizophrenia).
- Pre-existing neuromuscular disorders severely limiting mobility.
Other
- Hemodynamic instability or contraindication to mobilization.
Who the study is looking for
- Age ≥18 years.
- Histologically confirmed oral cancer.
- Planned free fibula or DCIA flap reconstruction.
- Ability to provide written informed consent.
- Sufficient comprehension of Dutch to complete questionnaires.
Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| UZ Leuven Coordinator of this site? Confirm its status | Leuven | Belgium | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.