NCT07857694Completed
Thoracic Radiotherapy Plus EGFR-TKI for Stage III EGFR-mutant Lung Adenocarcinoma
Patterns of Treatment Failure and Safety of Thoracic Radiotherapy Combined With EGFR-TKI in Stage III EGFR-mutant Lung Adenocarcinoma: a Multicenter Retrospective Cohort Study
Source: ClinicalTrials.gov · Last updated 5 Oct 2026
Brief summary (registry, in English)
Objective: To investigate the failure patterns, efficacy and safety of thoracic radiotherapy combined with EGFR-TKI in stage III unresectable non-small cell lung cancer harboring EGFR-sensitive mutations. Methods: This is a multicenter retrospective cohort study. Patients diagnosed with stage III unresectable EGFR-mutant non-small cell lung cancer who received thoracic radiotherapy plus EGFR-TKI between January 1, 2020 and December 31, 2024 were enrolled from five hospitals in Guangxi, including Laibin People's Hospital, The People's Hospital of Chongzuo, Liuzhou Traditional Chinese Medical Hospital, The First People's Hospital of Yulin, and The First Affiliated Hospital of Guilin Medical University. We will analyze progression patterns, progression-free survival, overall survival and treatment-related adverse events.
- Status (registry)
- Completed
- Study type
- Observational
- Enrollment
- 202 (actual)
- First submitted
- 29 Sept 2026
- Start date
- 1 Jan 2020
- Primary completion date
- 31 Dec 2024
- Lead sponsor
- Laibin People's Hospital
- Diseases
- Lung cancer
- NCT number
- NCT07857694
What you commit to
- Study type: Observational
- Participants enrolled: 202
- From 1 Jan 2020 to the primary completion date, 31 Dec 2024
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- 1\. Prior thoracic radiotherapy before the current treatment course. 2. Concurrent active malignant tumor. 3. Incomplete clinical, imaging or follow-up data. 4. Received radical surgical resection for lung cancer.
Who the study is looking for
- 1\. Histologically confirmed lung adenocarcinoma. 2. Stage III unresectable non-small cell lung cancer. 3. Presence of EGFR sensitive mutation (exon 19 deletion or L858R). 4. Received thoracic radiotherapy combined with EGFR-TKI treatment. 5. Complete medical records available for retrospective data collection.
Age in the registry: 18 years to 85 years · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| The First People's Hospital of Yulin City Coordinator of this site? Confirm its status | Yulin | China | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.