NCT07858006Not yet recruiting
Brain-computer Interface (BCI)-Guided Upper Limb Neurorehabilitation for Acute Stroke With the recoveriX System
Source: ClinicalTrials.gov · Last updated 7 Oct 2026
Brief summary (registry, in English)
Stroke is a leading cause of neurological disability and upper limb impairment. While conventional rehabilitation options exist, brain-computer interface (BCI)-based neurorehabilitation has emerged as a promising approach that records and decodes neural signals to drive rehabilitation devices or functional electrical stimulation. By re-coupling cortical motor intent to limb movement, BCI systems restore closed-loop neurofeedback and facilitate neuroplasticity through residual neural pathways. Motor intent is detected non-invasively via scalp electroencephalography (EEG), using characteristic changes in mu and beta rhythm activity known as event-related desynchronisation (ERD). This study aims to investigate how these electrophysiological signals change over time following stroke and their implications for BCI-based rehabilitation.
- Status (registry)
- Not yet recruiting
- Study type
- Interventional
- Enrollment
- 12 (estimated)
- First submitted
- 29 Sept 2026
- Start date
- Oct 2026
- Primary completion date
- Dec 2027
- Lead sponsor
- Tan Tock Seng Hospital
- Diseases
- Stroke
- NCT number
- NCT07858006
What you commit to
- Study type: Interventional
- Planned participants: 12
- From Oct 2026 to the primary completion date, Dec 2027
- No sites listed in no country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Presence of previous diagnosis of stroke
Other illness
- History of seizures or past history of epilepsy
- Disorders of consciousness or altered arousal states precluding active participation in the task.
Other
- Implanted pacemaker or continuous infusion pump
- Recent neurosurgery
- Medical instability deemed by study team
- Severe blindness
- Anticipated life expectancy \<6 months
- Hemodialysis
- Inability to obey 1-step commands
- Severe aphasia, or dysarthria
- Severe arm/hand pain (Visual Analog Scale \>4/10) or severe hemi anesthesia or spasticity in the paretic arm (modified Ashworth scale MAS \>2, total 4)
- Fixed shoulder or finger joint contractures, active arthritis in any upper limb joint
- Inability to tolerate upright supported sitting posture for at least 45 minutes
- Pregnant women will be excluded from the study as the safety of FES (electrical stimulations) on foetus is unclear.
Who the study is looking for
- Adults between age 21 to 80 years with hemorrhagic or ischemic stroke
- Stroke onset within 2-12 weeks
- Any demonstrated voluntary finger flexion or finger extension Oxford Medical Research Council (MRC) grade 0 to 4 (total 5)
- Montreal Cognitive Assessment (MoCA) \> 20
- Ability to understand written and spoken instructions, as well as stable medical and neurological status.
Age in the registry: 21 years to 80 years · Sex: All · Does not accept healthy volunteers
This page is information, not medical advice. Discuss any trial with your doctor.