NCT07864025Recruiting
Identification of Lesion Characteristics in Coronary Plaques Using Multimodality Intravascular Imaging and Novel Photon-counting CT in Stable Angina
Next Generation Coronary Plaque Characterisation and Computation of Flow Patterns: Photon-Counting Computed Tomography Coronary Angiography Versus State-of-the-Art Multimodality Intravascular Imaging
Source: ClinicalTrials.gov · Last updated 7 Oct 2026
Brief summary (registry, in English)
Coronary artery disease, caused by the furring up of the heart arteries by atherosclerosis, is a major cause of death in the UK. Despite existing therapies, adverse cardiovascular events remains high, especially in patients who have already had a heart attack, as some of these patients have aggressive atherosclerotic disease. If we could identify these vulnerable patients, then in wider clinical practice in the future we might be able to treat them better with new therapies that can otherwise be expensive or come with a risk of side-effects. Traditionally, the assessment of atherosclerotic disease and the identification of the plaques that will cause heart attacks is performed using invasive imaging - imaging taken by passing a wire into the arteries of the heart that has a camera on its tip. Invasive imaging, however, can be used only in patients with symptoms and has risks. Photon counting (PC) CT is a new CT system that has image quality comparable to invasive imaging and can be used in the community to examine individuals with stable angina symptoms. In this study we aim to compare how well PC-CT detects high-risk plaques compared with invasive imaging and in due course develop a platform that will expedite the analysis of CT images to allow its broad use in the clinical practice.
- Status (registry)
- Recruiting
- Study type
- Observational
- Enrollment
- 70 (estimated)
- First submitted
- 25 Sept 2026
- Start date
- 19 Aug 2026
- Primary completion date
- 3 Apr 2029
- Lead sponsor
- Queen Mary University of London
- Diseases
- Coronary artery disease
- NCT number
- NCT07864025
What you commit to
- Study type: Observational
- Planned participants: 70
- From 19 Aug 2026 to the primary completion date, 3 Apr 2029
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- History of previous coronary artery bypass surgery
- Previous heart transplantation
- Unable to receive treatment with aspirin, heparin, or thienopyridines
- Patient that requires surgical revascularisation
Other illness
- Recent acute coronary syndrome within \< 3 months
- Intravenous contrast allergy
- Extensive coronary artery disease (i.e. multiple chronic total occlusions) or tortuous coronary anatomy that does not allow assessment of the coronary arteries with NIRS-IVUS imaging
Lab values
- Renal failure (eGFR \<60ml/min/1.73m²)
- Decompensated heart failure, or left ventricular ejection fraction ≤30%
Age
- Age \>80 years
Other
- Unable to or unwilling to give informed consent
- Anticipated life expectancy \<1 year
- Pregnancy
Who the study is looking for
- Able and willing to give informed consent
- Between ages 18-79
- Patients with a stable coronary syndrome that had recent PC-CTA showing at least one lesion requiring further evaluation with intravascular imaging or fractional flow reserve and is considered suitable for PCI under IVUS guidance
Age in the registry: 18 years to 79 years · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| William Harvey Research Institute, Barts and The London, Queen Mary University of London Coordinator of this site? Confirm its status | London | United Kingdom | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.