NCT07866833Completed
Dysfunction of Respiratory Enzymes in Adults With Mental Illness (DREAM)
The Role of Mitochondrial Complex 1 (MC1) in Brain Dysfunction in Serious Mental Illness
Source: ClinicalTrials.gov · Last updated 8 Oct 2026
Brief summary (registry, in English)
This study tested whether intravenous methylene blue changes brain activity during a working-memory task differently in adults with schizophrenia taking stable antipsychotic medication and healthy volunteers. Each participant received methylene blue and a placebo solution with no methylene blue at separate visits and completed the task during functional magnetic resonance imaging (fMRI)
- Status (registry)
- Completed
- Study type
- Interventional
- Enrollment
- 53 (actual)
- First submitted
- 23 Sept 2026
- Start date
- 1 Jun 2020
- Primary completion date
- 31 Aug 2025
- Lead sponsor
- King's College London
- Diseases
- Schizophrenia
- NCT number
- NCT07866833
What you commit to
- Study type: Interventional
- Participants enrolled: 53
- From 1 Jun 2020 to the primary completion date, 31 Aug 2025
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Who the study is looking for
- Aged 18 to 65 years.
- Able to provide informed consent and have an adequate command of English.
- For participants in the schizophrenia group: diagnosis of schizophrenia according to DSM-5 criteria.
- For control participants: no current or past mental disorder.
- For control participants: no family history of schizophrenia or psychosis.
- No history of head trauma resulting in loss of consciousness.
- For female participants: negative pregnancy test.
- No history of neurological disorder or past or present neurological illness.
- No drug, alcohol, or substance dependence, except nicotine.
- No significant medical or physical disorder or illness.
- No contraindications to MRI.
- Not currently breastfeeding.
- No participation in a clinical trial or receipt of an investigational product within 90 days, five half-lives, or twice the duration of the biological effect of the investigational product, whichever is longer.
- Negative blood test for glucose-6-phosphate dehydrogenase deficiency.
- Not taking an SSRI, MAOI, or other serotonergic drug in the 6 weeks before the study.
- No cardiac arrhythmia on screening ECG.
- No history of renal failure.
- No significant history of heart disease or ECG abnormality.
Age in the registry: 18 years to 65 years · Sex: All · Accepts healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Robert Steiner MRI Unit Coordinator of this site? Confirm its status | London | United Kingdom | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.