NCT07867821Recruiting
Identification of New Biomarkers in Haemophilic Arthropathy Through Transcriptome Analysis
Individuazione di Nuovi Biomarker Nell'Artropatia Emofilica Attraverso Analisi Del Trascrittoma - Identification of New Biomarkers in Haemophilic Arthropathy Through Transcriptome Analysis
Source: ClinicalTrials.gov · Last updated 9 Oct 2026
Brief summary (registry, in English)
Chronic arthropathy is one of the most common complications of haemophilia, affecting up to 90 per cent of patients aged 4 and over in at least one joint. the study aims to assess gene expression in biological samples collected via synovectomy and joint replacement surgery, as well as in peripheral blood, in patients with severe haemophilia A or B; to compare these data with those from patients with osteoarthritis and rheumatoid arthritis; and to correlate the gene expression data with information relating to the clinical and laboratory phenotype, the history of inhibitors, and ultrasound and histological findings.
- Status (registry)
- Recruiting
- Study type
- Interventional
- Enrollment
- 20 (estimated)
- First submitted
- 5 Oct 2026
- Start date
- 24 Oct 2021
- Primary completion date
- 1 Mar 2027
- Lead sponsor
- Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico
- Diseases
- Haemophilia
- NCT number
- NCT07867821
What you commit to
- Study type: Interventional
- Planned participants: 20
- From 24 Oct 2021 to the primary completion date, 1 Mar 2027
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Current presence of an inhibitor (anti-FVIII or anti-FIX);
Other
- Inability to give informed consent to participate in the study.
Who the study is looking for
- Diagnosis of severe haemophilia A or B
- The need to perform therapeutic arthrocentesis, surgical synovectomy or orthopaedic joint replacement surgery for haemophilic arthropathy in all potentially affected joints.
- signed informed consent
Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Save your city in your profile to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Fondazione IRCCS Cà Granda Ospedale Maggiore Policlinico Coordinator of this site? Confirm its status | Milan | Italy | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.