NCT07868289Not yet recruiting
Effectiveness of Resonance Frequency Breathing Exercises in Patients With Systemic Lupus Erythematosus and Central Sensitization
Source: ClinicalTrials.gov · Last updated 13 Oct 2026
Brief summary (registry, in English)
Systemic Lupus Erythematosus (SLE) is a chronic autoimmune disease characterized by systemic inflammation, fatigue, central sensitization, and chronic pain. While physical exercise is strongly recommended to enhance functional capacity and manage fatigue, heightened central sensitivity and pain often limit adherence and clinical gains. Resonance frequency breathing (paced diaphragmatic breathing at 6 breaths per minute, 0.1 Hz) stimulates the baroreflex and facilitates autonomic regulation, which may alleviate central pain processing. This randomized controlled trial aims to evaluate the effects of resonance frequency breathing added to a standard exercise program compared with exercise alone on central sensitization, pain thresholds, fatigue, pain catastrophizing, functional capacity, respiratory muscle strength, disease activity, and quality of life in patients with SLE. Participants will be randomly allocated to either a Standard Exercise Group or a Standard Exercise + Resonance Breathing Group for an 8-week intervention.
- Status (registry)
- Not yet recruiting
- Study type
- Interventional
- Enrollment
- 38 (estimated)
- First submitted
- 5 Oct 2026
- Start date
- 1 Nov 2026
- Primary completion date
- 1 Jun 2027
- Lead sponsor
- Istanbul University - Cerrahpasa
- Diseases
- Lupus (SLE)
- NCT number
- NCT07868289
What you commit to
- Study type: Interventional
- Planned participants: 38
- From 1 Nov 2026 to the primary completion date, 1 Jun 2027
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Major surgical operation within the preceding 6 months
Other illness
- Active severe disease flare-up
Other
- Presence of severe cardiovascular or pulmonary contraindications that preclude safe participation in exercise or paced breathing training
- Current pregnancy
- Regular and ongoing practice of structured breathing exercises, pranayama, or yoga
Who the study is looking for
- Clinically diagnosed with Systemic Lupus Erythematosus (SLE) according to the 2019 ACR/EULAR classification criteria
- Aged between 18 and 65 years
- Central Sensitization Inventory (CSI) score of 40 or higher (CSI \>= 40)
- Stable medical therapy with no pharmacological regimen changes within the last 3 months
- Willing and cognitively able to provide written informed consent and adhere to the intervention protocol
Age in the registry: 18 years to 65 years · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Istanbul University-Cerrahpasa, Cerrahpasa Faculty of Medicine, Department of Internal Medicine, Division of Rheumatology Coordinator of this site? Confirm its status | Istanbul | Turkey (Türkiye) | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.