NCT07869472Not yet recruiting
Post-exercise Blood Pressure With Inorganic Nitrate
Effects of Inorganic Nitrate Supplementation on Post-exercise Hypotension Response Following Acute Exercise in Young Adults With Elevated Body Mass Index and Blood Pressure
Source: ClinicalTrials.gov · Last updated 9 Oct 2026
Brief summary (registry, in English)
This study is examining whether acute inorganic nitrate supplementation in the form of beetroot juice, paired with an acute bout of exercise, affects blood pressure and what is the magnitude of the difference compared to exercise alone.
- Status (registry)
- Not yet recruiting
- Study type
- Interventional
- Enrollment
- 12 (estimated)
- First submitted
- 30 Sept 2026
- Start date
- 15 Oct 2026
- Primary completion date
- 1 Jan 2027
- Lead sponsor
- University of Virginia
- Diseases
- Obesity, High blood pressure
- NCT number
- NCT07869472
What you commit to
- Study type: Interventional
- Planned participants: 12
- From 15 Oct 2026 to the primary completion date, 1 Jan 2027
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Has experienced significant weight loss \~3 kg in the last three months or taking any weight loss drugs
- Currently on hormone replacement of any kind
- Oral antibiotic use within previous four weeks including over-the-counter antibacterial mouthwash or a mouthwash containing chlorhexidine and unwilling to discontinue use
Other illness
- Current medical condition that prohibits exercising at high intensities
- History of medical conditions that would prohibit high intensity exercise, such as:, uncontrolled hypertension (≥140/90), diabetes, myocardial infarction, cerebrovascular event, known cardiovascular, pulmonary, renal, metabolic diseases, and acute or unstable disease other than high BMI and waist circumference
- Oral cancer/severe oral disease
Lab values
- Currently taking or have taken any of the following medications in the last 4 weeks (calcium channel blockers, statins, ACE or renin inhibitors, angiotensin receptor blockers, organic nitrates (e.g., nitroglycerine, alpha- or beta-blockers, diuretics, proton pump inhibitors, PDE-5 inhibitors (e.g., Cialis, Viagra), or xanthine oxidase inhibitors (e.g., Allopurinol))
Other
- Body mass index ≤ 29.9 Kg/m2
- Smoker within last 5 years
- Current injuries that would prohibit exercising on a stationary bike
- Currently restricted by medical doctor to engage in exercise
- Had hysterectomy or oophorectomy
- Pregnant women or planning to be pregnant, Fetuses, neonates, children, prisoners, cognitively impaired, non-English speaking participants
Who the study is looking for
- Willingness and ability to comply with scheduled visits and study procedures.
- Males and females, ages 18-40 years old
- Sedentary (\<150 minutes of moderate intensity aerobic exercise per week, or not engaged in a regular exercise program at all
- Resting systolic BP ≥ 120 mmHg.
- BMI ≥ 30 kg/m2
- Waist circumference ≥94 cm for males and ≥80 cm for females
- Be able to perform exercise on a cycle ergometer without assistance
- Stable medication regimen for the last 6 months
- Be able to discontinue the use of inorganic nitrate rich foods such as beets, arugula, spinach, celery, and grapefruit throughout the duration of the study.
Age in the registry: 18 years to 40 years · Sex: All · Accepts healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| University of Virginia Coordinator of this site? Confirm its status | Charlottesville | United States | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.