NCT07871487Recruiting
Tau Pathology in the Brain After Hip or Knee Replacement Surgery
Surgery and Postoperative Tau Pathology in Humans: A Translational Imaging and Biochemical Study to Explore Surgery-Induced Hallmarks of Alzheimer's Dementia
Source: ClinicalTrials.gov · Last updated 15 Oct 2026
Brief summary (registry, in English)
The goal of this observational study is to study whether major surgery is linked to changes in the brain that are typical of Alzheimer's disease. The study is a prospective observational study that will be carried out in Uppsala University Hospital. Adults aged 55-75 years who are healthy otherwise American Society of Anesthesiologists (ASA) 1-2 having a hip or knee replacement under spinal anesthesia, and a comparison group of people of the same age and sex with hip or knee arthrosis who are not having surgery will be included. The main questions it aims to answer are: * Does the amount of the protein tau in the brain increase in the two years after surgery? * Are changes in tau linked to inflammation in the blood and spinal fluid, and to changes in memory and thinking? Participants will: * Have brain scans with positron emission tomography (PET) and magnetic resonance imaging (MRI) scans before surgery and 12 and 24 months later * Give small samples of spinal fluid and blood * Complete memory and thinking tests at the same time points Researchers will compare the surgery group with the non-surgery group to see whether surgery is associated with more tau in the brain and with changes in memory and thinking.
- Status (registry)
- Recruiting
- Study type
- Observational
- Enrollment
- 30 (estimated)
- First submitted
- 6 Oct 2026
- Start date
- 1 Apr 2029
- Primary completion date
- 1 Apr 2029
- Lead sponsor
- Uppsala University Hospital
- Diseases
- Alzheimer disease
- NCT number
- NCT07871487
What you commit to
- Study type: Observational
- Planned participants: 30
- From 1 Apr 2029 to the primary completion date, 1 Apr 2029
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Other illness
- History of systemic inflammatory disorder
- Advanced cardiopulmonary disease
Other
- Mini-Mental State Examination (MMSE) score below 23
Who the study is looking for
- Surgical cohort:
- Age 55 to 75 years
- ASA physical status class 1 or 2
- Scheduled for hip or knee arthroplasty under regional (spinal) anesthesia at Uppsala University Hospital
- Written informed consent
- Non-surgical control cohort:
- Age 55 to 75 years
- ASA physical status class 1 or 2
- Hip or knee osteoarthritis, recruited from the orthopedic outpatient clinic at Uppsala University Hospital
- Not scheduled for surgery
- Written informed consent
Age in the registry: 55 years to 75 years · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Uppsala University Hospital Coordinator of this site? Confirm its status | Uppsala | Sweden | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.