NCT07871500CompletedPhase 4
Oliceridine Versus Sufentanil for Blood Pressure Control During Anesthesia Induction in Older Women With Hypertension Undergoing Gynecological Laparoscopic Surgery
Effects of Oliceridine and Sufentanil on Post-Induction Hypotension in Patients Undergoing Gynecological Abdominal Surgery
Source: ClinicalTrials.gov · Last updated 13 Oct 2026
Brief summary (registry, in English)
Blood pressure can fall during the start of general anesthesia, particularly in older patients with high blood pressure. This study compared two medicines, oliceridine and sufentanil, to assess their effects on low blood pressure during anesthesia induction in older women with hypertension undergoing gynecological laparoscopic surgery. This single-center randomized controlled trial enrolled 134 women aged 65 to 80 years at the Affiliated Hospital of Nantong University. Participants were assigned to receive either oliceridine or sufentanil, together with the same other anesthesia induction medicines. Blood pressure and heart rate were measured before induction, one minute after induction, immediately after insertion of the breathing tube, and one and five minutes after insertion. The main outcome was the proportion of participants who experienced low blood pressure during these measurements. Low blood pressure was defined as a mean arterial pressure below 65 mmHg or a decrease of at least 30% from the value measured before induction. Other assessments included changes and variability in blood pressure, heart rate, and the use of medicines to support blood pressure.
- Status (registry)
- Completed
- Phase (registry)
- Phase 4
- Study type
- Interventional
- Enrollment
- 134 (actual)
- First submitted
- 7 Oct 2026
- Start date
- 15 May 2026
- Primary completion date
- 15 Sept 2026
- Lead sponsor
- Xingguo Xu
- Diseases
- High blood pressure
- NCT number
- NCT07871500
What you commit to
- Study type: Interventional · Phase 4
- Participants enrolled: 134
- From 15 May 2026 to the primary completion date, 15 Sept 2026
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Use of analgesic or sedative medications within 48 hours before surgery.
Other illness
- Allergy to the study medications or contraindications to their use.
- Psychiatric or cognitive impairment preventing cooperation with study procedures.
- History of chronic pain, long-term heavy alcohol consumption, or opioid misuse.
Who the study is looking for
- Female participants aged 65 to 80 years.
- Body mass index of 18.5 to 30.0 kg/m².
- American Society of Anesthesiologists (ASA) physical status classification II or III.
- Scheduled for elective gynecological laparoscopic surgery under general anesthesia.
- Diagnosed with hypertension before surgery.
- Provided written informed consent to participate.
Age in the registry: 65 years to 80 years · Sex: Female · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Affiliated Hospital of Nantong University Coordinator of this site? Confirm its status | Nantong | China | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.