NCT07873060Recruiting
Comparing 10 Hz rTMS and iTBS for Adolescent Depression
A Randomized Controlled Trial Protocol Comparing 10 Hz rTMS and iTBS for Adolescent Depression: Clinical Efficacy, Neurocognitive and Neurobiological Mechanisms
Source: ClinicalTrials.gov · Last updated 14 Oct 2026
Brief summary (registry, in English)
This trial compares two transcranial magnetic stimulation (TMS) protocols-10 Hz rTMS and intermittent theta burst stimulation (iTBS)-in adolescents with major depressive disorder. Eighty participants aged 11-19 years will be randomly assigned to receive either 10 Hz rTMS or iTBS over a two-week period. Clinical symptoms, cognitive function, brain imaging, and neurophysiological measures will be assessed at baseline, immediately post-treatment, and at a 1-month follow-up to evaluate both the immediate and sustained therapeutic effects and underlying mechanisms.
- Status (registry)
- Recruiting
- Study type
- Interventional
- Enrollment
- 80 (estimated)
- First submitted
- 16 Sept 2026
- Start date
- 8 Oct 2026
- Primary completion date
- 31 Dec 2026
- Lead sponsor
- Qilu Hospital of Shandong University
- Diseases
- Depression
- NCT number
- NCT07873060
What you commit to
- Study type: Interventional
- Planned participants: 80
- From 8 Oct 2026 to the primary completion date, 31 Dec 2026
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Criteria the registry did not label
- \*\*Inclusion Criteria:\*\*
- Aged 11 to 19 years
- Meeting the DSM-5 criteria for MDD
- Absence of current or past psychotic symptoms (e.g., auditory or visual hallucinations)
- No comorbid schizophrenia, bipolar disorder, obsessive-compulsive disorder, post-traumatic stress disorder, panic disorder, or other severe psychiatric conditions
- No contraindications to MRI or TMS, including implanted cardiac pacemakers, neurostimulators, artificial metal heart valves, intracranial aneurysm clips, cochlear implants, or other metallic implants
- \*\*Exclusion Criteria:\*\*
- Alcohol or substance dependence
- Severe or unstable medical conditions, including neurological, endocrine, and rheumatic diseases, brain disorders, traumatic brain injury or surgery, and infectious diseases
- Recent receipt of rTMS or electroconvulsive therapy
- High suicide risk
- A history of epilepsy or unprovoked seizures
- Pregnancy
Age in the registry: 11 years to 19 years · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Shandong Mental Health Center Coordinator of this site? Confirm its status | Jinan | China | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.