NCT07874035Recruiting
Low Load Blood Flow Restriction Resistance Training in Colorectal Cancer Related Sarcopenia
Source: ClinicalTrials.gov · Last updated 21 Oct 2026
Brief summary (registry, in English)
PURPOSE: To investigate the effects of low-load resistance training combined with blood flow restriction on muscle strength, functional performance, and cancer-related fatigue in colorectal cancer survivors with probable sarcopenia. BACKGROUND: Muscle weakness and cancer-related fatigue are prevalent in colorectal cancer survivors with probable sarcopenia and are associated with adverse outcomes. High-load resistance training is often poorly tolerated in this population. Although low-load resistance training with blood flow restriction shows promise, colorectal cancer-specific randomized evidence remains limited. HYPOTHESES: It is hypothesized that low-load blood flow restriction resistance training will lead to significant improvements in muscle strength and functional performance and a significant reduction in cancer-related fatigue in colorectal cancer survivors with probable sarcopenia. RESEARCH QUESTION: Does low-load blood flow restriction resistance training lead to significant improvements in muscle strength and functional performance and a significant reduction in cancer-related fatigue in colorectal cancer survivors with probable sarcopenia?
- Status (registry)
- Recruiting
- Study type
- Interventional
- Enrollment
- 54 (estimated)
- First submitted
- 8 Oct 2026
- Start date
- 17 May 2026
- Primary completion date
- 15 Aug 2027
- Lead sponsor
- Ahmed Adel Ahmed Elsayed Ali Radwan
- Diseases
- Colorectal cancer
- NCT number
- NCT07874035
What you commit to
- Study type: Interventional
- Planned participants: 54
- From 17 May 2026 to the primary completion date, 15 Aug 2027
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Other illness
- Uncontrolled cardiovascular disease or hypertension.
- Severe peripheral vascular disease.
- Uncontrolled treatment-related complications, such as severe anemia or infection.
- Metastatic bone disease in the lower limbs.
- Neurological or musculoskeletal disorders limiting safe participation.
Other
- Any contraindication to resistance or blood flow restriction training.
- Recent thromboembolic events.
Who the study is looking for
- Colorectal cancer with probable sarcopenia.
- Age 40-59 years.
- Low muscle strength defined by EWGSOP2 criteria using the five-times sit-to-stand test (\>15 seconds without upper limb support).
- Current chemotherapy/radiotherapy or postoperative status with confirmed medical stability.
- Medical clearance for supervised exercise.
- Ability to follow instructions and complete assessments.
Age in the registry: 40 years to 59 years · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Private Clinics Coordinator of this site? Confirm its status | Cairo | Egypt | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.