NCT07874555Completed
A Real World Evidence Retrospective Data Collection Study of Edoxaban and Rivaroxaban
Evaluation of Recommended Once-daily Dosing of Edoxaban and Rivaroxaban in Patients With Atrial Fibrillation and Renal Dysfunction, the ERENAL Study in South Korea and Taiwan
Source: ClinicalTrials.gov · Last updated 15 Oct 2026
Brief summary (registry, in English)
This study aims to evaluate the recommended once-daily dosing of edoxaban and rivaroxaban in patients with atrial fibrillation (AF) and renal dysfunction in South Korea and Taiwan. The findings will contribute to the growing body of evidence needed to guide clinical practice in managing AF patients with renal impairment in Asian populations.
- Status (registry)
- Completed
- Study type
- Observational
- Enrollment
- 8265 (actual)
- First submitted
- 8 Oct 2026
- Start date
- Dec 2025
- Primary completion date
- Sept 2026
- Lead sponsor
- Daiichi Sankyo
- Diseases
- Atrial fibrillation
- NCT number
- NCT07874555
What you commit to
- Study type: Observational
- Participants enrolled: 8265
- From Dec 2025 to the primary completion date, Sept 2026
- 2 sites in 2 countries
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Criteria the registry did not label
- Patients will be entered into this study only if they meet all of the following criteria:
- Age ≥ 20 years at the index date. The index date is defined as the date of the first prescription of label-adherent edoxaban or rivaroxaban.
- Confirmed diagnosis of non-valvular atrial fibrillation (NVAF) prior to or on the index date.
- Most recently measured CrCl rate of 15 to 50 mL/min within 12 months prior to or on the index date.
- Received a prescription for label-adherent dosing (as defined in the protocol) of either: edoxaban (30 mg or 15 mg once daily), or rivaroxaban (15 mg or 10 mg once daily) on the index date.
- Patients with no prescription of any oral anticoagulants (including dabigatran, apixaban, rivaroxaban, edoxaban, and warfarin) for at least 30 days prior to the index date.
- Patients will be excluded from this study if they meet any of the following criteria:
- 1\. Patients who had at least one inpatient or two outpatient records of diagnosis code for any following conditions during the 12-month baseline assessment period prior to the prescription of edoxaban or rivaroxaban:
- End Stage Renal Disease (CrCl \< 15 mL/min).
- Venous thromboembolism (pulmonary embolism or deep vein thrombosis).
- Valvular heart disease.
Age in the registry: 20 years to - · Sex: All · Does not accept healthy volunteers
Sites (2)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Severance Cardiovascular Hospital Coordinator of this site? Confirm its status | Seoul | South Korea | Unknown status |
| Linkou Chang-Gung Memorial Hospital Coordinator of this site? Confirm its status | Taoyuan City | Taiwan | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.