NCT07874646Completed
Efficacy of Metformin With and Without Probiotics in Women With PCOS
Investigating the Efficacy of Metformin and Metformin With Probiotics in the Management of Polycystic Ovary Syndrome (PCOS): A Prospective Interventional Study
Source: ClinicalTrials.gov · Last updated 15 Oct 2026
Brief summary (registry, in English)
This prospective interventional study evaluated the effectiveness of metformin alone compared with metformin combined with probiotics in women with polycystic ovary syndrome (PCOS). The study included women aged 18-45 years diagnosed with PCOS according to the Rotterdam criteria. Participants received either metformin alone or metformin combined with probiotic supplementation for 12 weeks. The study assessed changes in hormonal parameters such as total testosterone (TT), sex hormone-binding globulin (SHBG), and free androgen index (FAI) to determine whether adding probiotics to metformin provided additional benefits in the management of PCOS.
- Status (registry)
- Completed
- Study type
- Interventional
- Enrollment
- 60 (actual)
- First submitted
- 6 Oct 2026
- Start date
- 27 Mar 2024
- Primary completion date
- 30 Aug 2024
- Lead sponsor
- Dhivyaprasath Palaniappan
- NCT number
- NCT07874646
What you commit to
- Study type: Interventional
- Participants enrolled: 60
- From 27 Mar 2024 to the primary completion date, 30 Aug 2024
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Use of hormonal medications or supplements within the past 3 months.
Other illness
- History of chronic gastrointestinal disorders
- Severe hepatic or renal impairment.
- Known allergy or intolerance to metformin.
- T2DM,Thyroid disorder,adrenal hyperplasia.
Other
- Pregnancy or lactation
- Intake of antiobesity and antidepressants in the last 3 months.
Who the study is looking for
- Premenopausal women aged 18-45 years.
- Diagnosis of PCOS based on the Rotterdam criteria.
- Body mass index (BMI) between 18.5 and 35 kg/m2.
Age in the registry: 18 years to 45 years · Sex: Female · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Vivekanandha Medical Care Hospital Coordinator of this site? Confirm its status | Tiruchengode | India | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.