NCT07875608CompletedPhase 2
Comparative Study of Intralesional Methotrexate Versus Intralesional Triamcinolone Acetonide in Treatment of Nail Psoriasis
Single Blinded Left to Right Comparative Study of Intralesional Methotrexate Versus Intralesional Triamcinolone Acetonide in Treatment of Nail Psoriasis
Source: ClinicalTrials.gov · Last updated 15 Oct 2026
Brief summary (registry, in English)
The goal of this clinical trial is to compare methotrexate injections with triamcinolone acetonide injections for treating nail psoriasis. Nail psoriasis can cause nail pitting, discoloration, thickening, and separation of the nail from the skin underneath. The study will also compare the safety of these treatments. The main questions it aims to answer are: * Which treatment produces greater improvement in nail psoriasis? * What side effects do participants experience with each treatment? Researchers will compare methotrexate with triamcinolone acetonide. Both medications will be injected intralesionally into the affected nail area. Participants will: * Receive intralesional injections according to the study treatment plan. * Attend clinic visits to assess changes in their affected nails and check for side effects. * Report any pain, discomfort, or other medical problems experienced during the study.
- Status (registry)
- Completed
- Phase (registry)
- Phase 2
- Study type
- Interventional
- Enrollment
- 25 (actual)
- First submitted
- 8 Oct 2026
- Start date
- 1 May 2023
- Primary completion date
- 10 Mar 2025
- Lead sponsor
- Tanta University
- Diseases
- Psoriasis
- NCT number
- NCT07875608
What you commit to
- Study type: Interventional · Phase 2
- Participants enrolled: 25
- From 1 May 2023 to the primary completion date, 10 Mar 2025
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Patients with concomitant onychomycosis.
- Patients using concomitant drug therapy affecting the nail.
- Patients with concomitant other dermatological disease or any systemic disease.
Other illness
- Patients with other nail disorders and diseases that interfere with the procedures and results, including nail trauma.
Other
- Pregnancy and lactation.
Who the study is looking for
- Patients with bilateral clinically significant nail psoriasis resistant to different treatment modalities.
- Patients who did not receive any topical or systemic treatment for nail psoriasis in the preceding 3 months and throughout the study.
Age in the registry: 16 years to 50 years · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Tanta University Hospital,Department of Dermatology and Venereology Coordinator of this site? Confirm its status | Tanta | Egypt | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.