NCT07875790Not yet recruiting
Cognitive Neurocomputational Task Reliability and Clinical Applications Consortium: Study 2
Cognitive Neurocomputational Task Reliability and Clinical Applications Consortium
Source: ClinicalTrials.gov · Last updated 23 Oct 2026
Brief summary (registry, in English)
In Study 2, investigators will recruit individuals with schizophrenia (SZ) and or schizoaffective disorder (SZA) and healthy controls (HC) using optimized behavioral tasks to replicate the behavioral findings from Study 1 and to assess additional psychometric properties such as test re-test reliability and practice effects. Investigators will obtain data on: A) clinical symptoms, with detailed assessment of hallucinations and delusions; B) community functioning; and C) functional capacity, allowing us to examine clinical validity. To generate a sample with sufficient variation in hallucinations and delusions, investigators will recruit the following groups that balance feasibility with clinical relevance: A) healthy controls \[HC, N=125\]; B) schizophrenia and schizoaffective disorder \[SZ/SZA, N=200\]). Investigators anticipate a \~20% screen fail/drop-out rate based upon prior studies. Thus, investigators will run an additional 40 SZ/SZA and 15 HC. Investigators will administer tasks optimized in Aim 1 without electroencephalogram (EEG), to this new sample of individuals with SZ/SZA and HC. All participants will be retested after approximately 28 days and repeat clinical assessments. Although the investigators' goal is to shorten task length using the Study 1 analyses, they will administer longer tasks than optimal for public dissemination in Study 2 to determine the minimum number of trials required for acceptable reliability. Study 2 will use the same clinical and functional measures as Study 1.
- Status (registry)
- Not yet recruiting
- Study type
- Interventional
- Enrollment
- 325 (estimated)
- First submitted
- 8 Oct 2026
- Start date
- Apr 2028
- Primary completion date
- Jun 2031
- Lead sponsor
- Washington University School of Medicine
- Diseases
- Schizophrenia
- NCT number
- NCT07875790
What you commit to
- Study type: Interventional
- Planned participants: 325
- From Apr 2028 to the primary completion date, Jun 2031
- 5 sites in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- self-reported medication non-compliance for at least the four previous weeks
- never having started medications
Other illness
- Diagnostic and Statistical Manual of Mental Disorders, 5th Edition (DSM-5)Psychosis or Bipolar Disorder diagnosis
- Family history of psychosis, bipolar, or Schizophrenia/Schizoaffective Disorder (SZ/SZA)
- additional exclusion criteria for the unmedicated individuals are:
Other
- Healthy Controls (HC):
- not in acute exacerbation requiring immediate hospitalization or treatment;
Who the study is looking for
- General Inclusion
- age 18 to 59 ;
- no substance disorder in past six months (confirmed with urine drug screens and breathalyzers);
- no clinically significant head injury or neurological disease;
- WechslerTest of Adult Reading (WTAR) score =16+.
- Group Specific Criteria: Schizophrenia/SchizoaffectiveDisorder (SZ/SZA):
- Diagnostic and Statistical Manual of Mental Disorders, 5th Edition (DSM-5) diagnosis ofschizophrenia or schizoaffective;
- no medication changes in prior month or anticipated in the next month or not taking medications;
- outpatient or partial hospital if unmedicated
- Healthy Controls (HC):
- no Diagnostic and Statistical Manual of Mental Disorders, 5th Edition (DSM-5) - Psychosis or BipolarDisorder;
- no family history of psychosis or bipolar
Age in the registry: 18 years to 59 years · Sex: All · Accepts healthy volunteers
Sites (5)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| University of Maryland, Baltimore Coordinator of this site? Confirm its status | Baltimore | United States | Unknown status |
| The University Of Chicago Coordinator of this site? Confirm its status | Chicago | United States | Unknown status |
| University of California, Irvine Coordinator of this site? Confirm its status | Irvine | United States | Unknown status |
| University of Minnesota Coordinator of this site? Confirm its status | Minneapolis | United States | Unknown status |
| Washington University Coordinator of this site? Confirm its status | St Louis | United States | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.