NCT07876180Completed
Effects of High-Intensity Interval Training and Exercise Snacking on Glycemic Control and Cardiorespiratory Fitness in Adults With Type 2 Diabetes Mellitus
Effects of High-Intensity Interval Training and Exercise Snacking on Glycemic Control and Cardiorespiratory Fitness in Adults With Type 2 Diabetes Mellitus: a Randomized Controlled Trial
Source: ClinicalTrials.gov · Last updated 15 Oct 2026
Brief summary (registry, in English)
This randomized controlled trial investigates whether two time-efficient forms of high-intensity exercise, high-intensity interval training (HIIT) and exercise snacking, improve glycemic control, cardiorespiratory fitness and other cardiometabolic risk factors in adults with type 2 diabetes mellitus. Over 12 weeks, participants were allocated to HIIT, exercise snacking, or a non-exercise control group. The study addresses two questions: whether each exercise modality improves these outcomes relative to no exercise, and whether accumulating vigorous exercise in brief bouts throughout the day produces adaptations comparable to those of conventional interval training performed in a single session.
- Status (registry)
- Completed
- Study type
- Interventional
- Enrollment
- 60 (actual)
- First submitted
- 8 Oct 2026
- Start date
- 20 Jan 2026
- Primary completion date
- 17 Jul 2026
- Lead sponsor
- University of Nis
- Diseases
- Type 2 diabetes
- NCT number
- NCT07876180
What you commit to
- Study type: Interventional
- Participants enrolled: 60
- From 20 Jan 2026 to the primary completion date, 17 Jul 2026
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Other illness
- Diagnosed nephropathy, liver disease or neuropathy
- Cardiovascular disease, including absolute contraindications to exercise such as unstable angina, recent myocardial infarction or uncontrolled symptomatic heart failure
- Uncontrolled hypertension (systolic blood pressure \>160 mmHg and/or diastolic blood pressure \>90 mmHg)
- History of respiratory disease, including pulmonary hypertension or chronic obstructive pulmonary disease
- Acute illness with recovery lasting longer than 3 weeks, or recovery from acute illness completed within the 3 weeks preceding the intervention Medical advice to avoid high-intensity or any physical activity due to potential worsening of an existing condition
Other
- Physically active according to IPAQ criteria (vigorous-intensity activity on ≥3 days/week achieving at least 600-1500 MET-min/week, or ≥5 days/week of any combination of walking, moderate- or vigorous-intensity activity achieving at least 600-3000 MET-min/week)
- Moderate to severe somatic or autonomic neuropathy, retinopathy, or other musculoskeletal or neurological impairments that contraindicate high-intensity exercise
- Electrocardiographic abnormalities judged clinically significant by a specialist physician
Who the study is looking for
- Adults aged 18-65 years
- Diagnosis of type 2 diabetes mellitus for at least 6 months, based on standard criteria (fasting plasma glucose ≥7.0 mmol/L \[≥126 mg/dL\] and/or HbA1c ≥6.5% \[≥48 mmol/mol\])
- Physically inactive according to the International Physical Activity Questionnaire (IPAQ): \<150 min/week of moderate-intensity or \<75 min/week of vigorous-intensity physical activity, or \<600 MET-min/week
- Treated with oral glucose-lowering medication, or with insulin for at least 3 months before enrollment
- Stable pharmacological treatment with no recent changes in the therapeutic regimen
- No musculoskeletal injuries or contraindications to high-intensity exercise
- No chronic conditions that are inadequately controlled by standard medical therapy or that could be aggravated by high-intensity exercise
- No episodes of severe hyperglycemia or hypoglycemia requiring hospitalization within the previous 3 months
Age in the registry: 18 years to 65 years · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Save your city in your profile to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Faculty of Sport and Physical Education, University of Niš Coordinator of this site? Confirm its status | Niš | Serbia | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.