NCT07879365Not yet recruiting
Effect of Weight Management on AMPK Activation in the Adjunctive Treatment of Endometrial Cancer
A Clinical Study of Weight Management-Induced AMPK Activation as an Adjunctive Treatment for Endometrial Cancer
Source: ClinicalTrials.gov · Last updated 16 Oct 2026
Brief summary (registry, in English)
This study will randomly assign overweight or obese patients with endometrial cancer undergoing fertility-sparing treatment to two groups. The intervention group will receive a comprehensive weight management program based on the DEAR principles of Diet, Exercise, Accompany, and Refresh, including intermittent fasting and structured aerobic exercise. The control group will receive balanced dietary guidance and self-directed exercise. Both groups will receive family and healthcare support, sleep monitoring, and stress-management support. By evaluating pathological complete response, body mass index, glucose and lipid metabolism, and serum AMP-activated protein kinase (AMPK) levels, this study aims to determine the effectiveness and safety of DEAR-based weight management in patients with endometrial cancer undergoing fertility-sparing treatment.
- Status (registry)
- Not yet recruiting
- Study type
- Interventional
- Enrollment
- 160 (estimated)
- First submitted
- 10 Oct 2026
- Start date
- 1 Jan 2027
- Primary completion date
- 31 Dec 2027
- Lead sponsor
- Peking University People's Hospital
- Diseases
- Endometrial cancer
- NCT number
- NCT07879365
What you commit to
- Study type: Interventional
- Planned participants: 160
- From 1 Jan 2027 to the primary completion date, 31 Dec 2027
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Other illness
- Patients with severe medical or surgical comorbidities, including urinary tract stones, a history of renal failure or severe renal impairment, familial dyslipidemia, severe liver disease, chronic metabolic acidosis, a history of pancreatitis, severe diabetes mellitus, active gallbladder disease, disorders of fat digestion, severe cardiovascular disease, cerebrovascular disease, or other serious comorbidities.
Other
- Patients with communication difficulties.
- Pregnant patients.
Who the study is looking for
- Aged 18 years or older.
- Diagnosed with endometrial cancer.
- Have undergone immunohistochemical staining of pathological tissue samples and sequencing analysis.
- Receiving fertility-sparing treatment.
- Body mass index ≥ 24 kg/m².
- Provided written informed consent to participate in the study.
Age in the registry: 18 years to - · Sex: Female · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Peking University People's Hospital Coordinator of this site? Confirm its status | Beijing | China | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.