NCT07880171Completed
Intensive Home-based Transcranial Direct Current Stimulation for Long COVID
Intensive Home-based Transcranial Direct Current Stimulation for Long COVID: a Randomised, Double-blind, Sham-controlled, Crossover Pilot Trial
Source: ClinicalTrials.gov · Last updated 19 Oct 2026
Brief summary (registry, in English)
The goal of this clinical trial is to learn if home-based transcranial direct current stimulation (tDCS) works to treat fatigue and other symptoms in adults with Long COVID. It will also learn about the safety and home adherence of this intervention. The main questions it aims to answer are: Does active tDCS lower fatigue severity (FAS score) compared to sham treatment? What are the effects of the treatment sequence on cognition, pain, anxiety, depression, and quality of life? Researchers will compare a sequence of active tDCS followed by sham tDCS to a sequence of sham tDCS followed by active tDCS in a crossover design to see if the intervention works. Participants will: Receive a tapered schedule of home-based tDCS over 3 weeks per intervention period (totaling 42 sessions per intervention, separated by a 4-week washout period) Complete symptom evaluations and cognitive/clinical tests at baseline, after Phase 1, and after Phase 2 Log their daily sessions to track home adherence and report any potential side effects
- Status (registry)
- Completed
- Study type
- Interventional
- Enrollment
- 40 (actual)
- First submitted
- 12 Oct 2026
- Start date
- 2 Sept 2025
- Primary completion date
- 25 Jan 2026
- Lead sponsor
- Hospital de Basurto
- Diseases
- Long COVID and ME/CFS
- NCT number
- NCT07880171
What you commit to
- Study type: Interventional
- Participants enrolled: 40
- From 2 Sept 2025 to the primary completion date, 25 Jan 2026
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Who the study is looking for
- Met the World Health Organization clinical case definition for post-COVID-19 condition
- Suffered severe fatigue (Fatigue Assessment Scale \[FAS\] score ≥42).
Criteria the registry did not label
- Participants were recruited from the specialised Long COVID Unit at Basurto University Hospital (Bilbao, Spain)
Age in the registry: 18 years to 65 years · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Hospital Universitario Basurto - Osakidetza / Basurto University Hospital - Basque Health System Coordinator of this site? Confirm its status | Bilbao | Spain | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.