NCT07880444Not yet recruiting
Effects of Daily Avocado Consumption on Sleep and Skin Health in Postmenopausal Females
Sleep and Skin Health Improvement Via Avocado-Induced Vascular Endothelial Responses in Postmenopausal Females With Poor Sleep
Source: ClinicalTrials.gov · Last updated 19 Oct 2026
Brief summary (registry, in English)
Poor sleep quality and accelerated skin aging are common in postmenopausal women and may be linked, in part, through impaired vascular function. Avocados contain monounsaturated fats, carotenoids, vitamin E, magnesium, fiber, and other bioactive compounds that may support vascular health and, in turn, improve sleep and skin health. This randomized controlled trial will evaluate whether consuming one medium Hass avocado daily for 8 weeks improves sleep quality and skin health compared with a calorie- and fatty-acid-matched safflower oil control in postmenopausal women with poor sleep quality and overweight or obesity. The study will enroll 74 postmenopausal women aged 50-65 years who have poor habitual sleep quality. Participants will be randomly assigned to consume either one medium Hass avocado per day or 27 g of safflower oil per day for 8 weeks. Sleep will be assessed using wrist actigraphy, at-home electroencephalography, sleep diaries, and validated sleep questionnaires. Skin hydration, elasticity, barrier function, collagen, pigmentation, and wrinkles will also be assessed. Vascular function will be measured using flow-mediated dilation and blood biomarkers. The investigators expect that daily avocado consumption will improve sleep quality, skin health, and vascular function compared with the control condition and will explore whether improvements in vascular function contribute to improvements in sleep and skin health.
- Status (registry)
- Not yet recruiting
- Study type
- Interventional
- Enrollment
- 74 (estimated)
- First submitted
- 6 Oct 2026
- Start date
- 1 Jan 2027
- Primary completion date
- Apr 2029
- Lead sponsor
- San Diego State University
- Diseases
- Obesity
- NCT number
- NCT07880444
What you commit to
- Study type: Interventional
- Planned participants: 74
- From 1 Jan 2027 to the primary completion date, Apr 2029
- No sites listed in no country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Excessive alcohol or drug use
- Current use of hormone replacement therapy
- Individuals using medications to regulate sleep
Other illness
- Individuals with chronic pain or major chronic disease/medication likely to affect study outcomes, including uncontrolled hypertension, prediabetes/type 2 diabetes, chronic kidney disease, COPD, autoimmune disease, recent cardiovascular event, or cancer within the past 24 months
- Psychiatric or neurologic disease/disorder likely to affect sleep
- Individuals with a diagnosed sleep disorder or high risk for sleep apnea, defined as a STOP-Bang score ≥3
- Allergy or intolerance to study foods
Other
- Current smokers
- Individuals with caffeine intake \>300 mg/day
- Individuals engaged in shift work
- Individuals planning time-zone travel during the study
- Pregnancy or lactation
- Individuals who dislike avocado and/or safflower oil, defined as a taste pleasantness rating \<50 mm on a 100-mm visual analog scale
- Individuals who habitually consume \>2 avocados per month
Who the study is looking for
- Postmenopausal women aged 50-65 years
- Individuals with overweight or obesity, defined as BMI 25-35 kg/m²
- Postmenopausal, defined as no menstrual period for at least 12 months
- Participants with poor habitual sleep quality, reflected by a global score \>5 on the Pittsburgh Sleep Quality Index (PSQI)
- Participants with Fitzpatrick skin types II-IV
- Participants willing to maintain their usual skin-care routine throughout the study, avoid excessive sun exposure, and not initiate new skin treatments
Age in the registry: 50 years to 65 years · Sex: Female · Accepts healthy volunteers
This page is information, not medical advice. Discuss any trial with your doctor.