NCT07880847Recruiting
MORPH-A - Multidisciplinary Obesity Rehabilitation & Psychophysical Health and Awareness
MORPH-A - Multidisciplinary Obesity Rehabilitation & Psychophysical Health and Awareness. A Multidisciplinary Outpatient Rehabilitation Programme for Obese Patients With Comorbidities
Source: ClinicalTrials.gov · Last updated 19 Oct 2026
Brief summary (registry, in English)
Obesity is a multifactorial chronic disease whose prevalence is steadily increasing worldwide, with substantial clinical, functional, psychological, and economic consequences. Body mass index (BMI) and staging systems such as the Edmonton Obesity Staging System (EOSS) allow obesity severity and associated cardiometabolic risk to be assessed, but they do not fully capture the complexity of the condition. Although its etiology is not yet fully understood, obesity results from the interaction of multiple factors. Individual susceptibility, including a hereditary component, interacts with psychobehavioral factors such as dysfunctional eating patterns and sedentary behavior, endocrine disorders in some cases, and broader sociocultural and environmental determinants, including socioeconomic status and lifestyle. This etiological complexity is reflected in the wide-ranging impact of obesity on health: in addition to increasing the risk of numerous clinical complications, obesity can substantially affect psychosocial well-being and quality of life. Given this multifactorial nature, current evidence and clinical guidelines support interventions that move beyond unidimensional approaches and address multiple dimensions of the condition in an integrated manner. The present study aims to evaluate the efficacy of an integrated multidisciplinary approach to obesity management compared with usual clinical care. The study hypothesis is that the combination of personalized nutritional, physiotherapeutic, and psychotherapeutic interventions can promote greater and more sustained weight loss, as well as better psycho-physiological outcomes.
- Status (registry)
- Recruiting
- Study type
- Interventional
- Enrollment
- 34 (estimated)
- First submitted
- 12 Oct 2026
- Start date
- 25 Aug 2026
- Primary completion date
- 31 May 2028
- Lead sponsor
- Istituti Clinici Scientifici Maugeri SpA
- Diseases
- Obesity
- NCT number
- NCT07880847
What you commit to
- Study type: Interventional
- Planned participants: 34
- From 25 Aug 2026 to the primary completion date, 31 May 2028
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Functional limitations that prevent participation in physical therapy sessions;
- Concurrent participation in other trials that could potentially interfere with the outcomes of this study.
Other illness
- Major psychiatric disorders, substance abuse;
- Obesity secondary to genetic and endocrinological disorders (e.g., hypercortisolism, acromegaly, overt hypothyroidism);
Age
- Age \< 18 years;
Other
- Non-Italian education, illiteracy, or relapse into illiteracy;
- Low motivation/interest or refusal to undergo assessment;
- Absence of comorbidities (EOSS \< or equal to 1)
Who the study is looking for
- Age \>18 years
- Class I or II obesity assessed at T0 with comorbid risk factors (EOSS \> or equal to 2) for which an SIO appropriateness form with a score \> or equal to 20 has been completed
- Patients who agree to begin treatment with a GLP-1 or GLP-1/GIP analog
- Fit for physical exercise
- Willingness to participate in the 12-week program
- Understanding of the Italian language and ability to complete the questionnaires
- Understanding of the research objectives and ability to provide informed consent.
Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Istituti Clinici Scientifici Maugeri IRCCS Coordinator of this site? Confirm its status | Pavia | Italy | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.