NCT07882875Not yet recruiting
Clinical Significance of Internal Carotid Artery Dolichoarteriopathy
Personalized Treatment Strategy for Internal Carotid Artery Dolichoarteriopathy Based on Objective Assessment of Cerebral Dysfunction and Outcome Prediction
Source: ClinicalTrials.gov · Last updated 20 Oct 2026
Brief summary (registry, in English)
This observational study aims to investigate the clinical significance of internal carotid artery dolichoarteriopathy, including tortuosity, kinking, and coiling, and to identify factors associated with cerebral dysfunction and adverse cerebrovascular outcomes. The study combines retrospective clinical data with prospective follow-up of patients with verified internal carotid artery dolichoarteriopathy. Anatomical, hemodynamic, neuroimaging, clinical, cognitive, and biomarker characteristics will be evaluated to develop and validate a multimodal approach to risk stratification. Outcomes will also be compared between patients managed surgically and conservatively according to routine clinical indications. Treatment decisions are made independently by the treating physicians and are not assigned by the study protocol.
- Status (registry)
- Not yet recruiting
- Study type
- Observational
- Enrollment
- 560 (estimated)
- First submitted
- 7 Oct 2026
- Start date
- Oct 2026
- Primary completion date
- Dec 2029
- Lead sponsor
- Kuban State Medical University
- Diseases
- Stroke
- NCT number
- NCT07882875
What you commit to
- Study type: Observational
- Planned participants: 560
- From Oct 2026 to the primary completion date, Dec 2029
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Acute ischemic or hemorrhagic stroke within 6 months before planned enrollment if the participant's condition prevents valid baseline assessment or study procedures.
- Myocardial infarction within the previous 3 months.
Other illness
- Unstable angina, NYHA class III-IV heart failure, or another decompensated cardiovascular condition that prevents safe participation.
- Severe cognitive impairment or dementia preventing valid informed consent or neuropsychological assessment, unless participation is legally permitted through an authorized representative.
- Active malignancy or systemic treatment expected to substantially affect the investigated biomarkers or prognosis.
- Decompensated respiratory, renal, or hepatic disease that may substantially affect safety or interpretation of study results.
- Psychiatric disorder or other condition preventing adequate communication or adherence to the study protocol.
Other
- Complete occlusion of the study internal carotid artery or brachiocephalic trunk that prevents valid assessment of the pathophysiological role of arterial tortuosity.
- Hemodynamically significant atherosclerotic stenosis of the internal carotid artery greater than 50% on the side relevant to the analysis when it represents the dominant alternative cause of impaired blood flow.
Who the study is looking for
- Age 18 to 75 years, inclusive.
- Verified pathological deformation of the internal carotid artery, including tortuosity, kinking, and/or coiling, confirmed by duplex ultrasound and/or angiographic imaging.
- Ability to undergo baseline clinical and neurological assessment and longitudinal follow-up.
- Written informed consent for participation and processing of personal data. Separate optional consent may be obtained for storage of residual biospecimens and genetic testing, where applicable.
Age in the registry: 18 years to 75 years · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Research Institute-Regional Clinical Hospital No. 1 Named After Prof. S.V. Ochapovsky Coordinator of this site? Confirm its status | Krasnodar | Russia | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.