NCT07883031Completed
Effects of Yerba Mate Supplementation on Metabolic Health, Physical Function, and Cognition in Older Adults With Excess Adiposity
Multisystem Effects of Yerba Mate Supplementation on Physiological, Cognitive, and Molecular Health in Overweight Older Adults
Source: ClinicalTrials.gov · Last updated 20 Oct 2026
Brief summary (registry, in English)
The purpose of this study was to find out whether taking yerba mate, a plant-based supplement, could improve health in adults aged 60 years or older with excess body fat. Researchers examined how the body uses fat during walking, blood cholesterol levels, body composition, strength, mobility, thinking skills, and well-being. They also explored changes in inflammation, gene activity, and gut bacteria. Participants took yerba mate capsules for six weeks and placebo capsules for six weeks, with a four-week break between the two periods. The placebo contained no yerba mate. The order was assigned by chance. Participants and the researchers conducting the tests did not know which capsules participants were taking during each period. Participants completed blood tests, body measurements, walking tests, strength and mobility tests, thinking tasks, and questionnaires. Researchers compared the results from the yerba mate and placebo periods.
- Status (registry)
- Completed
- Study type
- Interventional
- Enrollment
- 25 (actual)
- First submitted
- 8 Oct 2026
- Start date
- 15 Nov 2025
- Primary completion date
- 16 Jun 2026
- Lead sponsor
- University of North Alabama
- Diseases
- Obesity
- NCT number
- NCT07883031
What you commit to
- Study type: Interventional
- Participants enrolled: 25
- From 15 Nov 2025 to the primary completion date, 16 Jun 2026
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Antibiotic or probiotic use within the previous 3 months.
Other illness
- Major uncontrolled chronic disease.
- Diagnosed neurodegenerative disease or cognitive impairment, or Montreal Cognitive Assessment score below 18.
- Diagnosed psychiatric disorder or recent initiation of psychotropic medication.
- Uncontrolled hypertension, insulin-treated diabetes, or clinically significant hepatic or renal disease.
- Untreated sleep apnea or cardiac arrhythmias requiring antiarrhythmic therapy.
- Allergy to yerba mate or use of stimulant supplements.
Other
- Mobility limitations preventing completion of treadmill testing.
- Active smoking.
- Vegan or vegetarian diet.
- Physical activity exceeding 10 hours per week.
Who the study is looking for
- Age 60 years or older.
- Excess adiposity, defined by meeting at least two of the following criteria: body mass index ≥25 kg/m²; waist-to-hip ratio ≥0.90 for males or ≥0.85 for females; body fat percentage ≥25% for males or ≥35% for females.
- Ability to walk independently on a treadmill for at least 10 minutes.
- Ability to complete computerized cognitive assessments independently.
- Stable medication use for at least 3 months.
- Habitual caffeine intake below 300 mg/day.
- Ability to provide written informed consent and comply with study procedures.
Age in the registry: 60 years to - · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| University of North Alabama Coordinator of this site? Confirm its status | Florence | United States | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.