NCT07884110Recruiting
Liver Transplantation for Colorectal Cancer
Liver Transplantation for Colorectal Cancer: a Multicenter Registry
Source: ClinicalTrials.gov · Last updated 20 Oct 2026
Brief summary (registry, in English)
This is an observational study that will follow adults with stage IV colorectal cancer whose disease has spread only to the liver (not to other organs) and who are undergoing a liver transplant as part of their cancer treatment. Liver transplantation is being offered as a potentially curative option for patients whose liver metastases cannot be surgically removed. Researchers will review participants' medical records for up to 5 years after transplant to understand how this treatment affects survival, cancer recurrence, and safety. Participants will also be asked to complete a quality-of-life questionnaire (EORTC QLQ-C30). Taking part in this study does not involve any additional tests, visits, or procedures beyond the standard care participants would otherwise receive.
- Status (registry)
- Recruiting
- Study type
- Observational
- Enrollment
- 10 (estimated)
- First submitted
- 13 Oct 2026
- Start date
- 1 Jun 2026
- Primary completion date
- 30 Jun 2031
- Lead sponsor
- Pontificia Universidad Catolica de Chile
- Diseases
- Colorectal cancer
- NCT number
- NCT07884110
What you commit to
- Study type: Observational
- Planned participants: 10
- From 1 Jun 2026 to the primary completion date, 30 Jun 2031
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Other illness
- Evidence or history of extrahepatic metastases on CT (chest/abdomen/pelvis), MRI, or whole-body PET/CT
Other
- BRAF-mutated tumor
- Microsatellite instability-high (MSI-H) tumor
Who the study is looking for
- Adult patients aged 18 years or older at the time of evaluation for liver transplantation.
- Both male and female patients are eligible; there are no restrictions based on sex or gender.
- Patients with colorectal cancer (CRC) for whom liver transplantation has been approved as a potential treatment by the institutional liver transplant committee.
- Histologically confirmed adenocarcinoma of the colon or rectum.
- Patient not eligible for curative liver resection.
- Resection of the primary tumor ≥6 months before the planned date of transplantation.
- Standard surgical procedure with adequate resection margins, including a circumferential resection margin (CRM) of ≥2 mm for patients with rectal cancer.
- No signs of local recurrence on colonoscopy.
- Radiological and biomarker (CEA) response to treatment after at least 6 months of systemic therapy. For some higher-risk patients, the multidisciplinary tumor board may require 12 months of response.
- ECOG performance status 0-1.
- No signs or history of extrahepatic metastases on chest/abdomen/pelvis computed tomography (CAP CT) or magnetic resonance imaging (MRI), and on whole-body positron emission tomography/computed tomography (PET/CT).
- Carcinoembryonic antigen (CEA) level below 80 ng/mL at the time of listing for liver transplantation.
- BRAF wild-type and microsatellite stable (MSS).
- Deemed an appropriate transplant candidate by the liver transplant candidate evaluation committee and in accordance with transplant selection criteria.
- A potential living donor available and eligible under Chilean living-donor transplantation law.
Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Centro Del Cancer UC Coordinator of this site? Confirm its status | Santiago | Chile | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.