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NCT07884474Recruiting

Feasibility and Acceptability of Remote Saliva Collection

Source: ClinicalTrials.gov · Last updated 3 Nov 2026

Brief summary (registry, in English)

The purpose of this study is to evaluate the practicality and acceptability of collecting biological samples and health information from childhood survivors of acute lymphoblastic leukemia (ALL) and their siblings. Participants will provide saliva, blood, hair, and fingernail samples, complete questionnaires, and participate in sleep monitoring. The information collected will help researchers understand how cancer treatment and neighborhood conditions may affect stress hormones, inflammation, and long-term health. Primary Objective \- To evaluate the feasibility of collecting multiple biological specimens, surveys, and sleep assessment among child and adolescent survivors of ALL and their siblings.

Status (registry)
Recruiting
Study type
Observational
Enrollment
100 (estimated)
First submitted
25 Sept 2026
Start date
Dec 2026
Primary completion date
Apr 2028
Lead sponsor
St. Jude Children's Research Hospital
NCT number
NCT07884474

What you commit to

  • Study type: Observational
  • Planned participants: 100
  • From Dec 2026 to the primary completion date, Apr 2028
  • 1 site in 1 country
  • Visits and tests: ask the trial team, the registry does not list them

Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.

Who cannot take part

Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.

Prior treatment

  • Survivor and/or sibling has a history of prolonged treatment with steroid medications or systemic glucocorticoids for reasons other than ALL.

Other illness

  • Survivor and/or sibling has a diagnosis of Down's Syndrome.
  • Survivor and/or sibling has a diagnosis of autism spectrum disorder.
  • Survivor and/or sibling has a diagnosis of another pervasive developmental disorder not listed above.

Other

  • SURVIVORS and SIBLINGS
  • Survivor and/or sibling resides outside of the United States.
  • Inability or unwillingness of survivor and/or sibling and/or legal guardian/representative to give written informed consent.
    • CAREGIVERS Note: There are no exclusion criteria for caregivers.

Who the study is looking for

  • SURVIVORS
  • The survivor is a childhood survivor of Acute Lymphocytic Leukemia (ALL).
  • The survivor was treated on one of the following St. Jude Total Therapy Studies:
    • TOTAL Therapy study XVI for Newly Diagnosed Patients with ALL (TOTXVI) OR
    • Total Therapy for Children with Acute Lymphoblastic Leukemia and Lymphoma (TOT17)
  • The survivor is cancer-free.
  • The survivor is at least 5 years out from the ALL diagnosis.
  • The survivor is at least 2 years out from completion of treatment.
  • The survivor did not receive cranial therapy as part of ALL therapy.
  • The survivor is aged ≥8 to 18 years old at the time of enrollment.
  • The survivor has completed their After Completion of Therapy (ACT) clinic consultation.
  • The survivor is able to speak and read English.
  • The survivor has internet access.
    • SIBLINGS
  • The sibling has a brother or sister who is an ALL survivor participating in this study.
  • The sibling is aged ≥8 to18 years old at the time of enrollment.
  • The sibling is able to speak and read English.
  • The sibling has internet access.
    • CAREGIVERS
  • The caregiver provides primary care or support to an ALL survivor that is in this study.
  • The caregiver resides in the home full-time with enrolled survivor and sibling.
  • The caregiver is able to speak and read English.
  • The caregiver has internet access.
  • The caregiver is willing and able to assist with at home biospecimen collection.

Age in the registry: 8 years to 18 years · Sex: All · Accepts healthy volunteers

Full criteria on ClinicalTrials.gov

Sites (1)

Sites in registry order. Pick your city on the disease page to sort them by distance.

SiteCityCountrySite status
St. Jude Children's Research Hospital
Coordinator of this site? Confirm its status		MemphisUnited StatesRecruiting

This page is information, not medical advice. Discuss any trial with your doctor.