NCT07886502Not yet recruiting
Upper Airway Morphology and Physiology During Graded Positive Pressure and Nasal High Flow: An MRI Study
Effects of Graded Positive Airway Pressure and Nasal High Flow Interfaces on Upper Airway Morphology and Breathing Physiology in Healthy Volunteers and COPD Patients: A Controlled MRI Study
Source: ClinicalTrials.gov · Last updated 21 Oct 2026
Brief summary (registry, in English)
This study investigates the effects of graded nasal high flow (NHF) and continuous positive airway pressure (CPAP) on upper airway morphology and respiratory physiology in healthy volunteers and patients with COPD. Participants undergo baseline MRI and physiological assessment followed by NHF at 30 and 60 L/min and CPAP at 4 and 12 cmH₂O. The primary aim is to determine whether graded NHF and CPAP induce dose-dependent changes in upper airway morphology, including upper airway volume and cross-sectional area, during MRI scans.
- Status (registry)
- Not yet recruiting
- Study type
- Observational
- Enrollment
- 20 (estimated)
- First submitted
- 1 Oct 2026
- Start date
- 1 Oct 2026
- Primary completion date
- 1 Dec 2027
- Lead sponsor
- Klinikum Dortmund Wirbelsäulenchirurgie
- Diseases
- COPD
- NCT number
- NCT07886502
What you commit to
- Study type: Observational
- Planned participants: 20
- From 1 Oct 2026 to the primary completion date, 1 Dec 2027
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Contraindications to MRI (e.g., claustrophobia or ferromagnetic implants)
- Alcohol, drug, medication, or other substance abuse
Other illness
- Physical or mental conditions limiting study participation or compliance, as judged by the investigator
Other
- Inability or refusal to provide informed consent
- Contraindications to mask-based positive airway pressure or nasal high flow
- Pregnancy
- Any other objective reason preventing study participation, as determined by the investigator
Who the study is looking for
- Written informed consent
- Age ≥18 years
- BMI ≤30 kg/m²
Age in the registry: 18 years to - · Sex: All · Accepts healthy volunteers
Sites (1)
Sites in registry order. Save your city in your profile to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Klinikum Dortmund Coordinator of this site? Confirm its status | Dortmund | Germany | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.