NCT07886788Active, not recruiting
Study of Grape Consumption in Adaptation to Seasonal Photoperiod
Source: ClinicalTrials.gov · Last updated 21 Oct 2026
Brief summary (registry, in English)
The goal of this randomized clinical trial is to learn whether consuming grapes during their natural season can help the body adapt to the shorter daylight hours of winter. The study includes men and women aged 30-70 years with either normal weight or overweight or obesity and metabolic dysfunction-associated steatotic liver disease (MASLD). The main questions it aims to answer are: * Does seasonal grape consumption change circulating microRNAs, small molecules involved in regulating gene activity? * Does grape consumption influence sleep, physical activity, metabolic markers, body composition, muscle function, and gut bacteria during the transition to winter? Within each population group, researchers will compare participants consuming yogurt with freeze-dried grape powder with participants consuming the same yogurt without grape powder. Both groups will receive the same Mediterranean-style dietary guidance. Participants will: * Consume two yogurts daily for 3 weeks, either with or without a total daily dose of 16 grams of freeze-dried grape powder, equivalent to approximately 80 grams of fresh grapes. * Complete a further 2 weeks of follow-up without the grape intervention. * Attend an initial information visit and three assessment visits for blood sampling, stool sample collection, and measurements of body composition and muscle function. * Wear a wrist device to monitor sleep and physical activity. * Complete questionnaires, dietary records, and a sleep diary.
- Status (registry)
- Active, not recruiting
- Study type
- Interventional
- Enrollment
- 46 (actual)
- First submitted
- 14 Oct 2026
- Start date
- 28 Sept 2026
- Primary completion date
- 6 Nov 2026
- Lead sponsor
- University Rovira i Virgili
- Diseases
- Obesity
- NCT number
- NCT07886788
What you commit to
- Study type: Interventional
- Participants enrolled: 46
- From 28 Sept 2026 to the primary completion date, 6 Nov 2026
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Women receiving hormonal contraceptive treatment.
- Antibiotic treatment within the 4 weeks before enrollment.
- Chronic treatment with corticosteroids and/or nonsteroidal anti-inflammatory drugs (NSAIDs).
Other illness
- Acute or chronic liver disease of an etiology other than MASLD.
- Active inflammatory, infectious, or neoplastic disease.
- Milk protein allergy.
Other
- Alcohol consumption exceeding 10 g/day or use of other toxic substances.
- Pregnancy.
- Grape-related food intolerances.
Who the study is looking for
- Men and women aged 30-70 years.
- Body mass index (BMI) between 18.5 and 39.9 kg/m².
- Written informed consent.
- Membership in one of the following population groups:
- Normal-weight group: BMI between 18.5 and 24.9 kg/m².
- Overweight or obesity group: BMI between 25.0 and 39.9 kg/m² and a diagnosis of metabolic dysfunction-associated steatotic liver disease (MASLD).
Age in the registry: 30 years to 70 years · Sex: All · Accepts healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Hospital Universitari Joan XXIII - Unitat d'Investigació Clínica, IRB CatSud Coordinator of this site? Confirm its status | Tarragona | Spain | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.